(1R)-N-[α-tert-butyl N-(benzyloxycarbonyl)amino-L-γ-glutamyl]-1-(5-tetrazolyl)butylamine

Base Information

Chemical Name:(1R)-N-[α-tert-butyl N-(benzyloxycarbonyl)amino-L-γ-glutamyl]-1-(5-tetrazolyl)butylamine
CAS No.:277758-49-3
Molecular Formula:C₂₂H₃₂N₆O₅
Molecular Weight:460.533
Hs Code.:

Synonyms:(1R)-N-[α-tert-butyl N-(benzyloxycarbonyl)amino-L-γ-glutamyl]-1-(5-tetrazolyl)butylamine

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Chemical Property of (1R)-N-[α-tert-butyl N-(benzyloxycarbonyl)amino-L-γ-glutamyl]-1-(5-tetrazolyl)butylamine

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Technology Process of (1R)-N-[α-tert-butyl N-(benzyloxycarbonyl)amino-L-γ-glutamyl]-1-(5-tetrazolyl)butylamine

There total 7 articles about (1R)-N-[α-tert-butyl N-(benzyloxycarbonyl)amino-L-γ-glutamyl]-1-(5-tetrazolyl)butylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42918-89-8
(R)-2-(N-benzyloxycarbonylamino)pentanoic acid

: 277758-49-3
(1R)-N-[α-tert-butyl N-(benzyloxycarbonyl)amino-L-γ-glutamyl]-1-(5-tetrazolyl)butylamine

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / tetrahydrofuran / 0.17 h / -15 °C

2: gaseous NH₃ / tetrahydrofuran / 1.75 h / -15 - 20 °C

3: 84 percent / p-TsCl; pyridine / CH₂Cl₂ / 4.5 h / 0 - 20 °C

4: 64 percent / NaN₃; NH₄Cl / dimethylformamide / 20 h / 90 °C

5: 93 percent / H₂ / 10percent Pd/C / ethanol / 22 h

6: tetrahydrofuran / 3.67 h / -20 - 20 °C

With pyridine; sodium azide; ammonia; hydrogen; ammonium chloride; triethylamine; p-toluenesulfonyl chloride; 10percent Pd/C; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm991119p

Reference yield:

: 277758-44-8
(2R)-2-(benzyloxycarbonylamino)pentanonitrile

: 277758-49-3
(1R)-N-[α-tert-butyl N-(benzyloxycarbonyl)amino-L-γ-glutamyl]-1-(5-tetrazolyl)butylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / NaN₃; NH₄Cl / dimethylformamide / 20 h / 90 °C

2: 93 percent / H₂ / 10percent Pd/C / ethanol / 22 h

3: tetrahydrofuran / 3.67 h / -20 - 20 °C

With sodium azide; hydrogen; ammonium chloride; 10percent Pd/C; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm991119p

Reference yield:

: 277758-40-4
(2R)-2-(benzyloxycarbonylamino)pentanamide

: 277758-49-3
(1R)-N-[α-tert-butyl N-(benzyloxycarbonyl)amino-L-γ-glutamyl]-1-(5-tetrazolyl)butylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / p-TsCl; pyridine / CH₂Cl₂ / 4.5 h / 0 - 20 °C

2: 64 percent / NaN₃; NH₄Cl / dimethylformamide / 20 h / 90 °C

3: 93 percent / H₂ / 10percent Pd/C / ethanol / 22 h

4: tetrahydrofuran / 3.67 h / -20 - 20 °C

With pyridine; sodium azide; hydrogen; ammonium chloride; p-toluenesulfonyl chloride; 10percent Pd/C; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm991119p