1-[3-(4-(2-chlorophenyl)-piperazin-1-yl)-2-hydroxypropyl]-3-methyl-2,4-dioxo-5,5-diphenylimidazolidine hydrochloride

Base Information

Chemical Name:1-[3-(4-(2-chlorophenyl)-piperazin-1-yl)-2-hydroxypropyl]-3-methyl-2,4-dioxo-5,5-diphenylimidazolidine hydrochloride
CAS No.:1370333-42-8
Molecular Formula:C₂₉H₃₁ClN₄O₃*ClH
Molecular Weight:555.504
Hs Code.:

Synonyms:1-[3-(4-(2-chlorophenyl)-piperazin-1-yl)-2-hydroxypropyl]-3-methyl-2,4-dioxo-5,5-diphenylimidazolidine hydrochloride

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Chemical Property of 1-[3-(4-(2-chlorophenyl)-piperazin-1-yl)-2-hydroxypropyl]-3-methyl-2,4-dioxo-5,5-diphenylimidazolidine hydrochloride

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Technology Process of 1-[3-(4-(2-chlorophenyl)-piperazin-1-yl)-2-hydroxypropyl]-3-methyl-2,4-dioxo-5,5-diphenylimidazolidine hydrochloride

There total 2 articles about 1-[3-(4-(2-chlorophenyl)-piperazin-1-yl)-2-hydroxypropyl]-3-methyl-2,4-dioxo-5,5-diphenylimidazolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1370333-33-7
1-[3-(4-(2-chlorophenyl)-piperazin-1-yl)-2-hydroxypropyl]-3-methyl-2,4-dioxo-5,5-diphenylimidazolidine

: 1370333-42-8
1-[3-(4-(2-chlorophenyl)-piperazin-1-yl)-2-hydroxypropyl]-3-methyl-2,4-dioxo-5,5-diphenylimidazolidine hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 4 ℃;
DOI:10.1016/j.bmc.2012.02.009

Reference yield:

: 39512-50-0
N-(o-Chlorophenyl)piperazine

: 1041926-38-8
C₁₉H₁₈N₂O₃

: 1370333-42-8
1-[3-(4-(2-chlorophenyl)-piperazin-1-yl)-2-hydroxypropyl]-3-methyl-2,4-dioxo-5,5-diphenylimidazolidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 0.2 h / Microwave irradiation; Neat (no solvent)

2: hydrogenchloride / methanol / 4 °C

With hydrogenchloride; In methanol;
DOI:10.1016/j.bmc.2012.02.009