N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide hydrochloride

Base Information

• Chemical Name: N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide hydrochloride
• CAS No.: 1228652-97-8
• Molecular Formula: C₁₃H₁₄F₃N₃O₂*ClH
• Molecular Weight: 337.729

Synonyms:N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide hydrochloride

Chemical Property of N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide hydrochloride

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Technology Process of N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide hydrochloride

There total 1 articles about N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[2-(3-trifluoro-methyl-benzoylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butyl ester (1228652-17-2) → N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide hydrochloride (1228652-97-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 4h;

Reference yield: 45.0%

4-hydroxy-4-(6-methoxy-pyridin-2-yl)-cyclohexanone (1228652-22-9) + N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide hydrochloride (1228652-97-8) → N-({1-[4-hydroxy-4-(6-methoxy-pyridin-2-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide + N-({1-[4-hydroxy-4-(6-methoxy-pyridin-2-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

Guidance literature:

With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/ml300260s

Reference yield: 42.0%

4-hydroxy-4-(2-isopropyl-thiazol-5-yl)-cyclohexanone (708274-14-0) + N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide hydrochloride (1228652-97-8) → N-({1-[4-hydroxy-4-(2-isopropyl-thiazol-5-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide + N-({1-[4-hydroxy-4-(2-isopropyl-thiazol-5-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

Guidance literature:

With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/ml300260s

upstream raw materials:

3-[2-(3-trifluoro-methyl-benzoylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

N-({1-[4-(6-Methoxy-pyridin-3-yl)-cyclohex-3-enyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

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