3-[2-(4-chlorophenyl)ethyl]-5-[(4-methylphenyl]sulphonyl]-1,2,4-thiadiazole

Base Information

Chemical Name:3-[2-(4-chlorophenyl)ethyl]-5-[(4-methylphenyl]sulphonyl]-1,2,4-thiadiazole
CAS No.:1202651-27-1
Molecular Formula:C₁₇H₁₅ClN₂O₂S₂
Molecular Weight:378.903
Hs Code.:

Synonyms:3-[2-(4-chlorophenyl)ethyl]-5-[(4-methylphenyl]sulphonyl]-1,2,4-thiadiazole

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Chemical Property of 3-[2-(4-chlorophenyl)ethyl]-5-[(4-methylphenyl]sulphonyl]-1,2,4-thiadiazole

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Technology Process of 3-[2-(4-chlorophenyl)ethyl]-5-[(4-methylphenyl]sulphonyl]-1,2,4-thiadiazole

There total 1 articles about 3-[2-(4-chlorophenyl)ethyl]-5-[(4-methylphenyl]sulphonyl]-1,2,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.7%

: 19158-51-1
P-toluenesulfonyl cyanide

: 1202651-28-2
5-[2-(4-chlorophenyl)ethyl]-1,3,4-oxathiazol-2-one

: 1202651-27-1
3-[2-(4-chlorophenyl)ethyl]-5-[(4-methylphenyl]sulphonyl]-1,2,4-thiadiazole

Guidance literature:: In 1,2-dichloro-benzene; at 160 ℃; for 1h;

Reference yield:

: 1202651-27-1
3-[2-(4-chlorophenyl)ethyl]-5-[(4-methylphenyl]sulphonyl]-1,2,4-thiadiazole

: 98280-30-9
5-chloro-4-amino-2-methyl-phenol

: 1202651-26-0
2-chloro-4-({3-[2-(4-chlorophenyl)ethyl]-1,2,4-thiadiazol-5-yl}oxy)-5-methylaniline

Guidance literature:: 5-chloro-4-amino-2-methyl-phenol; With potassium carbonate; In acetonitrile; at 20 ℃; for 0.5h;

3-[2-(4-chlorophenyl)ethyl]-5-[(4-methylphenyl]sulphonyl]-1,2,4-thiadiazole; In acetonitrile; at 50 ℃; for 12h;

Reference yield:

: 1202651-27-1
3-[2-(4-chlorophenyl)ethyl]-5-[(4-methylphenyl]sulphonyl]-1,2,4-thiadiazole

: 98280-30-9
5-chloro-4-amino-2-methyl-phenol

: 2-chloro-4-({3-[2-(4-chlorophenyl)ethyl]-1,2,4-thiadiazol-5-yl}oxy)-5-methyl-N-[(Z)-piperidin-1-ylmethylidene]aniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 0.5 h / 20 °C

1.2: 12 h / 50 °C

2.1: toluene; methanol / 18 h / Reflux

With potassium carbonate; In methanol; toluene; acetonitrile;