(4S)-4-(benzyloxy)-5,5-dimethoxypentanoic acid

Base Information

Chemical Name:(4S)-4-(benzyloxy)-5,5-dimethoxypentanoic acid
CAS No.:888504-78-7
Molecular Formula:C₁₄H₂₀O₅
Molecular Weight:268.31
Hs Code.:

Synonyms:(4S)-4-(benzyloxy)-5,5-dimethoxypentanoic acid

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Chemical Property of (4S)-4-(benzyloxy)-5,5-dimethoxypentanoic acid

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Technology Process of (4S)-4-(benzyloxy)-5,5-dimethoxypentanoic acid

There total 4 articles about (4S)-4-(benzyloxy)-5,5-dimethoxypentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 888504-78-7
(4S)-4-(benzyloxy)-5,5-dimethoxypentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl chloride; DMSO / CH₂Cl₂ / 0.75 h / -78 °C

1.2: 73 percent / Et₃N; pyridinium p-toluenesulfonate / methanol / 120 h / 23 °C

2.1: NaH; [15]crown-5; water / benzene / 16 h / Heating

2.2: 73 percent / benzene / 24 h / Heating

With oxalyl dichloride; 15-crown-5; water; sodium hydride; dimethyl sulfoxide; In dichloromethane; benzene;
DOI:10.1002/hlca.200690058

Reference yield:

: 75629-74-2
(S)-(-)-Tetrahydro-5-oxo-2-furancarboxaldehyde

: 888504-78-7
(4S)-4-(benzyloxy)-5,5-dimethoxypentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 11.20 g / acetyl chloride / methanol / 8 h / 23 °C

2: sodium hydride; 15-crown-15; H₂O / benzene / 5 h / Heating

3: 10.0 g / benzene / 16 h / Heating

With 15-crown-15; water; sodium hydride; acetyl chloride; In methanol; benzene;
DOI:10.1016/j.tetasy.2004.04.028

Reference yield:

: 731862-45-6
(4S)-4-(dimethoxymethyl)butano-4-lactone

: 888504-78-7
(4S)-4-(benzyloxy)-5,5-dimethoxypentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride; 15-crown-15; H₂O / benzene / 5 h / Heating

2: 10.0 g / benzene / 16 h / Heating

With 15-crown-15; water; sodium hydride; In benzene;
DOI:10.1016/j.tetasy.2004.04.028