Technology Process of 2-(3,4-DIMETHOXYBENZYL)-3-(N-BENZYL-4-PIPERIDINE)PROPIONIC ACID(DONEPEZIL INTERMEDIATE)
There total 4 articles about 2-(3,4-DIMETHOXYBENZYL)-3-(N-BENZYL-4-PIPERIDINE)PROPIONIC ACID(DONEPEZIL INTERMEDIATE) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; lithium hydroxide;
In
tetrahydrofuran; methanol;
at 24 - 28 ℃;
for 96h;
DOI:10.1002/ejoc.202000695
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 40 h / 0 - 28 °C / Inert atmosphere
2: lithium hydroxide; water / methanol; tetrahydrofuran / 96 h / 24 - 28 °C
With
water; triethylamine; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/ejoc.202000695
- Guidance literature:
-
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen; acetic acid; sodium acetate / 42 h / 24 - 28 °C
2: triethylamine / dichloromethane / 40 h / 0 - 28 °C / Inert atmosphere
3: lithium hydroxide; water / methanol; tetrahydrofuran / 96 h / 24 - 28 °C
With
palladium 10% on activated carbon; water; hydrogen; sodium acetate; acetic acid; triethylamine; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/ejoc.202000695
