Technology Process of (P)-(-)-2,7,12-tris<((R)-2-phenoxypropanoyl)oxy>-10,15-dihydro-5H-tribenzo
cyclononene
There total 5 articles about (P)-(-)-2,7,12-tris<((R)-2-phenoxypropanoyl)oxy>-10,15-dihydro-5H-tribenzocyclononene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / 1) tert-BuOK / dimethylformamide / 1) 10 min, 2) 1 h
2: 90 percent / H2 / 10percent Pd/charcoal / CH2Cl2; methanol / 836 Torr / 1) water bath, 2) 15-20 deg C, 9 h
3: 100 percent / BBr3 / CH2Cl2 / 1) -78 deg C, 10 min, 2) r.t., 1 h
4: 195 mg / (dimethylamino)pyridine, dicycylohexylcarbodiimide / dimethylformamide / 0 deg C, 5 min -> 20 deg C, 3 h
With
dmap; potassium tert-butylate; hydrogen; boron tribromide; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00332a042
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 80 percent / 65percent HClO4 / 10percent Pd/charcoal / dioxane; ethanol / 20 h / 55 - 60 °C
2: 90 percent / 1) tert-BuOK / dimethylformamide / 1) 10 min, 2) 1 h
3: 90 percent / H2 / 10percent Pd/charcoal / CH2Cl2; methanol / 836 Torr / 1) water bath, 2) 15-20 deg C, 9 h
4: 100 percent / BBr3 / CH2Cl2 / 1) -78 deg C, 10 min, 2) r.t., 1 h
5: 195 mg / (dimethylamino)pyridine, dicycylohexylcarbodiimide / dimethylformamide / 0 deg C, 5 min -> 20 deg C, 3 h
With
dmap; perchloric acid; potassium tert-butylate; hydrogen; boron tribromide; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00332a042
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 90 percent / H2 / 10percent Pd/charcoal / CH2Cl2; methanol / 836 Torr / 1) water bath, 2) 15-20 deg C, 9 h
2: 100 percent / BBr3 / CH2Cl2 / 1) -78 deg C, 10 min, 2) r.t., 1 h
3: 195 mg / (dimethylamino)pyridine, dicycylohexylcarbodiimide / dimethylformamide / 0 deg C, 5 min -> 20 deg C, 3 h
With
dmap; hydrogen; boron tribromide; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00332a042
