5-(1,1-dimethylethyl)-2-(α-ethoxy-β-oxopropyl)cyclohex-1-ene-1-carboxaldehyde

Base Information

• Chemical Name: 5-(1,1-dimethylethyl)-2-(α-ethoxy-β-oxopropyl)cyclohex-1-ene-1-carboxaldehyde
• CAS No.: 86902-49-0
• Molecular Formula: C₁₆H₂₆O₃
• Molecular Weight: 266.381
• Mol file: 86902-49-0.mol

Synonyms:5-(1,1-dimethylethyl)-2-(α-ethoxy-β-oxopropyl)cyclohex-1-ene-1-carboxaldehyde

Chemical Property of 5-(1,1-dimethylethyl)-2-(α-ethoxy-β-oxopropyl)cyclohex-1-ene-1-carboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(1,1-dimethylethyl)-2-(α-ethoxy-β-oxopropyl)cyclohex-1-ene-1-carboxaldehyde

There total 4 articles about 5-(1,1-dimethylethyl)-2-(α-ethoxy-β-oxopropyl)cyclohex-1-ene-1-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(1,1-dimethylethyl)-2-(α-ethoxyprop-2-enyl)cyclohex-1-enecarboxaldehyde (86902-39-8) → 5-(1,1-dimethylethyl)-2-(α-ethoxy-β-oxopropyl)cyclohex-1-ene-1-carboxaldehyde (86902-49-0)

Guidance literature:

With oxygen; copper(l) chloride; palladium dichloride; In water; N,N-dimethyl-formamide; at 45 ℃; for 2.5h;

DOI:10.1021/jo00169a056

Reference yield:

4-(tert-butyl)-2-(hydroxymethylene)cyclohexan-1-one (22252-96-6) → 5-(1,1-dimethylethyl)-2-(α-ethoxy-β-oxopropyl)cyclohex-1-ene-1-carboxaldehyde (86902-49-0)

Guidance literature:

Multi-step reaction with 4 steps

1: Me₃N / tetrahydrofuran

2: 1.) sec-BuLi, anh. zinc chloride / 1.) THF, -78 deg C, 10 min, 2.) -78 deg C, 10 min, -78 deg C to room temp., 10 min

3: pyridinium tosylate / CH₂Cl₂ / 0.17 h / 23 °C

4: O₂, cuprous chloride, palladium chloride / dimethylformamide; H₂O / 2.5 h / 45 °C

With sec.-butyllithium; oxygen; pyridinium p-toluenesulfonate; copper(l) chloride; palladium dichloride; zinc(II) chloride; trimethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo00169a056

Reference yield:

4-(1,1-dimethylethyl)-2-<<(trimethylsilyl)oxy>methylene>-1-(α-ethoxyprop-2-enyl)cyclohexan-1-ol (86902-69-4) → 5-(1,1-dimethylethyl)-2-(α-ethoxy-β-oxopropyl)cyclohex-1-ene-1-carboxaldehyde (86902-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium tosylate / CH₂Cl₂ / 0.17 h / 23 °C

2: O₂, cuprous chloride, palladium chloride / dimethylformamide; H₂O / 2.5 h / 45 °C

With oxygen; pyridinium p-toluenesulfonate; copper(l) chloride; palladium dichloride; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo00169a056

upstream raw materials:

5-(1,1-dimethylethyl)-2-(α-ethoxyprop-2-enyl)cyclohex-1-enecarboxaldehyde

4-(tert-butyl)-2-(hydroxymethylene)cyclohexan-1-one

4-(1,1-dimethylethyl)-2-<<(trimethylsilyl)oxy>methylene>-1-(α-ethoxyprop-2-enyl)cyclohexan-1-ol

2-<<(trimethylsilyl)oxy>methylene>-4-(1,1-dimethylethyl)cyclohexanone