methyl (3R,αS)-3-[N-tert-butyldimethylsilyloxy-N-(α-methylbenzyl)amino]-3-phenylpropanoate

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Chemical Name:methyl (3R,αS)-3-[N-tert-butyldimethylsilyloxy-N-(α-methylbenzyl)amino]-3-phenylpropanoate
CAS No.:1236003-31-8
Molecular Formula:C₂₄H₃₅NO₃Si
Molecular Weight:413.632
Hs Code.:

Synonyms:methyl (3R,αS)-3-[N-tert-butyldimethylsilyloxy-N-(α-methylbenzyl)amino]-3-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (3R,αS)-3-[N-tert-butyldimethylsilyloxy-N-(α-methylbenzyl)amino]-3-phenylpropanoate

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Technology Process of methyl (3R,αS)-3-[N-tert-butyldimethylsilyloxy-N-(α-methylbenzyl)amino]-3-phenylpropanoate

There total 1 articles about methyl (3R,αS)-3-[N-tert-butyldimethylsilyloxy-N-(α-methylbenzyl)amino]-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1236003-30-7
(S)-N-tert-butyldimethylsilyloxy-N-(α-methylbenzyl)amine

: 103-26-4,1754-62-7
methyl cinnamate

: 1236003-31-8
methyl (3R,αS)-3-[N-tert-butyldimethylsilyloxy-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Guidance literature:: (S)-N-tert-butyldimethylsilyloxy-N-(α-methylbenzyl)amine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

methyl cinnamate; In tetrahydrofuran; hexane; at -78 ℃; for 10h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.25h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2010.04.027

Reference yield: 88.0%

: 1236003-31-8
methyl (3R,αS)-3-[N-tert-butyldimethylsilyloxy-N-(α-methylbenzyl)amino]-3-phenylpropanoate

: methyl (3R,αS)-3-[N-(α-methylbenzyl)amino]-3-phenylpropanoate

Guidance literature:: methyl (3R,αS)-3-[N-tert-butyldimethylsilyloxy-N-(α-methylbenzyl)amino]-3-phenylpropanoate; With acetic acid; zinc; at 20 ℃; for 60h; Sonication; Inert atmosphere;

With sodium hydroxide; In water; ethyl acetate;
DOI:10.1016/j.tet.2010.04.027

Reference yield: 70.0%

: 1236003-31-8
methyl (3R,αS)-3-[N-tert-butyldimethylsilyloxy-N-(α-methylbenzyl)amino]-3-phenylpropanoate

: (3R,αS)-N(2)-α-methylbenzyl-3-phenylisoxazolidin-5-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tet.2010.04.027