2,2-dichloro-N-((1R,2S)-3-fluoro-1-(4-(5-fluoro-6-(methylsulfonamidomethyl)pyridin-3-yl)phenyl)-1-hydroxypropan-2-yl)acetamide

Base Information

Chemical Name:2,2-dichloro-N-((1R,2S)-3-fluoro-1-(4-(5-fluoro-6-(methylsulfonamidomethyl)pyridin-3-yl)phenyl)-1-hydroxypropan-2-yl)acetamide
CAS No.:1454904-15-4
Molecular Formula:C₁₈H₁₉Cl₂F₂N₃O₄S
Molecular Weight:482.335
Hs Code.:

Synonyms:2,2-dichloro-N-((1R,2S)-3-fluoro-1-(4-(5-fluoro-6-(methylsulfonamidomethyl)pyridin-3-yl)phenyl)-1-hydroxypropan-2-yl)acetamide

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Chemical Property of 2,2-dichloro-N-((1R,2S)-3-fluoro-1-(4-(5-fluoro-6-(methylsulfonamidomethyl)pyridin-3-yl)phenyl)-1-hydroxypropan-2-yl)acetamide

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Technology Process of 2,2-dichloro-N-((1R,2S)-3-fluoro-1-(4-(5-fluoro-6-(methylsulfonamidomethyl)pyridin-3-yl)phenyl)-1-hydroxypropan-2-yl)acetamide

There total 7 articles about 2,2-dichloro-N-((1R,2S)-3-fluoro-1-(4-(5-fluoro-6-(methylsulfonamidomethyl)pyridin-3-yl)phenyl)-1-hydroxypropan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116-54-1
dichloroacetic acid methyl ester

: C₁₆H₁₉F₂N₃O₃S

: 1454904-15-4
2,2-dichloro-N-((1R,2S)-3-fluoro-1-(4-(5-fluoro-6-(methylsulfonamidomethyl)pyridin-3-yl)phenyl)-1-hydroxypropan-2-yl)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In methanol; at 60 ℃; for 18h;

Reference yield:

: 1052114-46-1
tert-butyl ((1R,2S)-3-fluoro-1-hydroxy-1-(4-iodophenyl)propan-2-yl)carbamate

: 1454904-15-4
2,2-dichloro-N-((1R,2S)-3-fluoro-1-(4-(5-fluoro-6-(methylsulfonamidomethyl)pyridin-3-yl)phenyl)-1-hydroxypropan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

2: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

4: nickel dichloride; sodium tetrahydroborate / methanol / 1 h / 5 - 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 5 - 20 °C

6: trifluoroacetic acid / dichloromethane / 1 h / 5 - 20 °C

7: N-ethyl-N,N-diisopropylamine / methanol / 18 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; caesium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; nickel dichloride; In 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 1382801-14-0
(4S,5R)-4-fluoromethyl-2,2-dimethyl-5-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]oxazolidine-3-carboxylic acid tert-butyl ester

: 1454904-15-4
2,2-dichloro-N-((1R,2S)-3-fluoro-1-(4-(5-fluoro-6-(methylsulfonamidomethyl)pyridin-3-yl)phenyl)-1-hydroxypropan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

2: nickel dichloride; sodium tetrahydroborate / methanol / 1 h / 5 - 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 5 - 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 5 - 20 °C

5: N-ethyl-N,N-diisopropylamine / methanol / 18 h / 60 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; nickel dichloride; In 1,4-dioxane; methanol; dichloromethane; water;