ethyl 5,6-bis(4-chlorophenyl)-3-[(4,4-difluoropiperidin-1-yl)methyl]pyrazine-2-carboxylate

Base Information

• Chemical Name: ethyl 5,6-bis(4-chlorophenyl)-3-[(4,4-difluoropiperidin-1-yl)methyl]pyrazine-2-carboxylate
• CAS No.: 811442-20-3
• Molecular Formula: C₂₅H₂₃Cl₂F₂N₃O₂
• Molecular Weight: 506.379
• Mol file: 811442-20-3.mol

Synonyms:ethyl 5,6-bis(4-chlorophenyl)-3-[(4,4-difluoropiperidin-1-yl)methyl]pyrazine-2-carboxylate

Chemical Property of ethyl 5,6-bis(4-chlorophenyl)-3-[(4,4-difluoropiperidin-1-yl)methyl]pyrazine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5,6-bis(4-chlorophenyl)-3-[(4,4-difluoropiperidin-1-yl)methyl]pyrazine-2-carboxylate

There total 1 articles about ethyl 5,6-bis(4-chlorophenyl)-3-[(4,4-difluoropiperidin-1-yl)methyl]pyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4-difluoropiperidine (21987-29-1) + ethyl 5,6-bis(4-chlorophenyl)-3-formylpyrazine-2-carboxylate (811441-09-5) → ethyl 5,6-bis(4-chlorophenyl)-3-[(4,4-difluoropiperidin-1-yl)methyl]pyrazine-2-carboxylate (811442-20-3)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield: 80.0%

ethyl 5,6-bis(4-chlorophenyl)-3-[(4,4-difluoropiperidin-1-yl)methyl]pyrazine-2-carboxylate (811442-20-3) + C7H17AlN2 → 5,6-bis(4-chlorophenyl)-3-[(4,4-difluoropiperidin-1-yl)methyl]-N-piperidin-1-ylpyrazine-2-carboxamide

Guidance literature:

ethyl 5,6-bis(4-chlorophenyl)-3-[(4,4-difluoropiperidin-1-yl)methyl]pyrazine-2-carboxylate; C₇H₁₇AlN₂; In toluene; at 50 ℃; for 18h;

With hydrogenchloride; In water; toluene; at 0 ℃; for 3h;

With sodium hydroxide; In dichloromethane; water; toluene; pH=6 - 7;

Reference yield: 78.0%

ethyl 5,6-bis(4-chlorophenyl)-3-[(4,4-difluoropiperidin-1-yl)methyl]pyrazine-2-carboxylate (811442-20-3) + C8H16AlF2N → 5,6-bis(4-chlorophenyl)-N-(4,4-difluorocyclohexyl)-3-[(4,4-difluoropiperidin-1-yl)methyl]pyrazine-2-carboxamide

Guidance literature:

ethyl 5,6-bis(4-chlorophenyl)-3-[(4,4-difluoropiperidin-1-yl)methyl]pyrazine-2-carboxylate; C₈H₁₆AlF₂N; In toluene; at 50 ℃; for 19h;

With hydrogenchloride; In water; toluene; at 0 ℃; for 1h;

upstream raw materials:

4,4-difluoropiperidine

ethyl 5,6-bis(4-chlorophenyl)-3-formylpyrazine-2-carboxylate