2,3-Bis-(3,4,5-trimethoxy-benzoyl)-succinic acid diethyl ester

Base Information

• Chemical Name: 2,3-Bis-(3,4,5-trimethoxy-benzoyl)-succinic acid diethyl ester
• CAS No.: 188249-84-5
• Molecular Formula: C₂₈H₃₄O₁₂
• Molecular Weight: 562.571
• Mol file: 188249-84-5.mol

Synonyms:2,3-Bis-(3,4,5-trimethoxy-benzoyl)-succinic acid diethyl ester

Chemical Property of 2,3-Bis-(3,4,5-trimethoxy-benzoyl)-succinic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2,3-Bis-(3,4,5-trimethoxy-benzoyl)-succinic acid diethyl ester

There total 1 articles about 2,3-Bis-(3,4,5-trimethoxy-benzoyl)-succinic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl trimethoxybenzoyl acetate (3044-56-2) → 2,3-Bis-(3,4,5-trimethoxy-benzoyl)-succinic acid diethyl ester (188249-84-5)

Guidance literature:

With N-Bromosuccinimide; potassium tert-butylate; In tetrahydrofuran; at 20 ℃;

DOI:10.1080/00397910701578123

Reference yield:

2,3-Bis-(3,4,5-trimethoxy-benzoyl)-succinic acid diethyl ester (188249-84-5) → 3,4-dimethyl-2,5-bis-(3,4,5-trimethoxy-phenyl)-furan (72730-16-6)

Guidance literature:

Multi-step reaction with 3 steps

1: p-TsOH / benzene / 8 h / Heating

2: LiAlH₄ / tetrahydrofuran / 12 h / Heating

3: 65 percent / H₂ / PdO / tetrahydrofuran; CHCl₃ / 48 h / 80 °C / 45003.6 Torr

With lithium aluminium tetrahydride; hydrogen; toluene-4-sulfonic acid; trimethyleneglycol; In tetrahydrofuran; chloroform; benzene;

DOI:10.1080/00397919708006815

Reference yield:

2,3-Bis-(3,4,5-trimethoxy-benzoyl)-succinic acid diethyl ester (188249-84-5) → 2,5-Bis-(3,4,5-trimethoxy-phenyl)-furan-3,4-dicarboxylic acid diethyl ester (194021-22-2)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 8h; Yield given; Heating;

DOI:10.1080/00397919708006815

upstream raw materials:

ethyl trimethoxybenzoyl acetate

Downstream raw materials:

2,5-Bis-(3,4,5-trimethoxy-phenyl)-furan-3,4-dicarboxylic acid diethyl ester

3,4-dimethyl-2,5-bis-(3,4,5-trimethoxy-phenyl)-furan

[4-Hydroxymethyl-2,5-bis-(3,4,5-trimethoxy-phenyl)-furan-3-yl]-methanol