5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride

Base Information

Chemical Name:5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride
CAS No.:1426309-48-9
Molecular Formula:C₁₄H₁₁F₂N₅*ClH
Molecular Weight:323.733
Hs Code.:

Synonyms:5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride

Suppliers and Price of 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 7 raw suppliers

Chemical Property of 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride

Chemical Property:

Purity/Quality:: 99.9% ^*data from raw suppliers

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Technology Process of 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride

There total 4 articles about 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1350653-26-7
5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile

: 1426309-48-9
5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride

Guidance literature:: 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile; With sodium methylate; In methanol; ethanol; at 20 ℃; Inert atmosphere;

With ammonium chloride; In methanol; ethanol; at 65 ℃; for 3.5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b00449

Reference yield:

: 256504-39-9
ethyl 5-amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate

: 1426309-48-9
5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanesulfonic acid; lithium chloride / ethanol / 4.5 h / Inert atmosphere; Reflux

2.1: sodium methylate; formamide / methanol; ethanol / 2.5 h / 95 - 125 °C / Inert atmosphere

3.1: trichlorophosphate / sulfolane; acetonitrile / 1.5 h / 103 - 107 °C / Inert atmosphere

4.1: sodium methylate / methanol; ethanol / 20 °C / Inert atmosphere

4.2: 3.5 h / 65 °C / Inert atmosphere

With methanesulfonic acid; sodium methylate; formamide; lithium chloride; trichlorophosphate; In sulfolane; methanol; ethanol; acetonitrile; 4.1: |Pinner Amidine Synthesis / 4.2: |Pinner Amidine Synthesis;
DOI:10.1021/acs.jmedchem.7b00449

Reference yield:

: 1361232-73-6
5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide

: 1426309-48-9
5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / sulfolane; acetonitrile / 1.5 h / 103 - 107 °C / Inert atmosphere

2.1: sodium methylate / methanol; ethanol / 20 °C / Inert atmosphere

2.2: 3.5 h / 65 °C / Inert atmosphere

With sodium methylate; trichlorophosphate; In sulfolane; methanol; ethanol; acetonitrile; 2.1: |Pinner Amidine Synthesis / 2.2: |Pinner Amidine Synthesis;
DOI:10.1021/acs.jmedchem.7b00449