5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-valerylphenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

Base Information

Chemical Name:5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-valerylphenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS No.:170647-93-5
Molecular Formula:C₃₄H₄₀ClFN₄O₄S
Molecular Weight:655.233
Hs Code.:

Synonyms:5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-valerylphenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

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Chemical Property of 5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-valerylphenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

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Technology Process of 5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-valerylphenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

There total 11 articles about 5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-valerylphenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 170647-92-4
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-(2-n-butyl-1,3-dithian-2-yl)-phenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

: 170647-93-5
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-valerylphenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: With N-Bromosuccinimide; water; In acetonitrile; for 3h; Ambient temperature;
DOI:10.1021/jm00019a004

Reference yield:

: 51436-99-8
2-fluoro-4-bromotoluene

: 170647-93-5
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-valerylphenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / aq. NaOH, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / ethanol / 4.5 h / 90 °C

2: Br₂ / CCl₄ / Heating; Irradiation

3: 1.) NaH / 1.) DMF, 50 deg C, 2 h, 2.) DMF, 50 deg C, 3 h

4: 36 percent / NBS, water / acetonitrile / 3 h / Ambient temperature

With sodium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; bromine; sodium hydride; In tetrachloromethane; ethanol; acetonitrile;
DOI:10.1021/jm00019a004

Reference yield:

: 25017-08-7
1-(4-chlorophenyl)pentan-1-one

: 170647-93-5
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2-<2-chloro-5-valerylphenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 7 steps

1: nitric acid / 0.5 h / 0 °C

2: BF₃*Et₂O / CH₂Cl₂ / Ambient temperature

3: 80 percent / SnCl₂*2H₂O, conc. HCl / tetrahydrofuran / Ambient temperature

4: 1.) Conc_. HCl, NaNO₂, 2.) SnCl₂*2H₂O, conc. HCl / 1.) THF, 0 deg C, 1 h, 2.) THF, 5 deg C, overnight

5: 2.) Et₃N / 1.) toluene, 50 deg C, 2 h, 2.) toluene, 90 deg C, 16 h

6: 1.) NaH / 1.) DMF, 50 deg C, 2 h, 2.) DMF, 50 deg C, 3 h

7: 36 percent / NBS, water / acetonitrile / 3 h / Ambient temperature

With hydrogenchloride; N-Bromosuccinimide; boron trifluoride diethyl etherate; water; nitric acid; sodium hydride; triethylamine; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm00019a004