(S)-tert-butyl (4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yl)carbamate
CAS No.:1446434-30-5
Molecular Formula:C₂₁H₂₁Cl₂NO₂
Molecular Weight:390.309
Hs Code.:

Synonyms:(S)-tert-butyl (4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yl)carbamate

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Chemical Property of (S)-tert-butyl (4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yl)carbamate

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Technology Process of (S)-tert-butyl (4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yl)carbamate

There total 3 articles about (S)-tert-butyl (4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1446434-26-9
(S)-tert-butyl (1,2-dihydronaphthalen-1-yl)carbamate

: 151169-75-4
3,4-dichlophenylboronic acid

: 1446434-30-5
(S)-tert-butyl (4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yl)carbamate

Guidance literature:: With caesium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; johnphos; In water; toluene; at 100 ℃; for 4h; Reagent/catalyst; Inert atmosphere; Microwave irradiation;
DOI:10.1021/ol4017113

Reference yield:

: 1446434-14-5
(R_s)-N-[(S)-1,2-dihydronaphthalen-1-yl]-2-methylpropane-2-sulfinamide

: 1446434-30-5
(S)-tert-butyl (4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane; methanol / 0.33 h / 20 °C / Inert atmosphere

2: potassium carbonate / 1,4-dioxane / 20 °C / Inert atmosphere

3: bis(dibenzylideneacetone)-palladium⁽⁰⁾; johnphos; caesium carbonate / toluene; water / 4 h / 100 °C / Inert atmosphere; Microwave irradiation

With hydrogenchloride; potassium carbonate; caesium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; johnphos; In 1,4-dioxane; methanol; water; toluene; 3: |Suzuki Coupling;
DOI:10.1021/ol4017113

Reference yield:

: 1446469-35-7
(S)-1,2-dihydronaphthalen-1-amine

: 1446434-30-5
(S)-tert-butyl (4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / 1,4-dioxane / 20 °C / Inert atmosphere

2: bis(dibenzylideneacetone)-palladium⁽⁰⁾; johnphos; caesium carbonate / toluene; water / 4 h / 100 °C / Inert atmosphere; Microwave irradiation

With potassium carbonate; caesium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; johnphos; In 1,4-dioxane; water; toluene; 2: |Suzuki Coupling;
DOI:10.1021/ol4017113