3-({(S)-1-[3-({(S)-1-[3-((S)-2-tert-Butoxycarbonylamino-4-isopropoxycarbonyl-butyrylamino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoic acid benzyl ester

Base Information

• Chemical Name: 3-({(S)-1-[3-({(S)-1-[3-((S)-2-tert-Butoxycarbonylamino-4-isopropoxycarbonyl-butyrylamino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoic acid benzyl ester
• CAS No.: 259665-77-5
• Molecular Formula: C₅₁H₅₈N₆O₁₁
• Molecular Weight: 931.055

Synonyms:3-({(S)-1-[3-({(S)-1-[3-((S)-2-tert-Butoxycarbonylamino-4-isopropoxycarbonyl-butyrylamino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoic acid benzyl ester

Chemical Property of 3-({(S)-1-[3-({(S)-1-[3-((S)-2-tert-Butoxycarbonylamino-4-isopropoxycarbonyl-butyrylamino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-({(S)-1-[3-({(S)-1-[3-((S)-2-tert-Butoxycarbonylamino-4-isopropoxycarbonyl-butyrylamino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoic acid benzyl ester

There total 5 articles about 3-({(S)-1-[3-({(S)-1-[3-((S)-2-tert-Butoxycarbonylamino-4-isopropoxycarbonyl-butyrylamino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-({(S)-1-[3-((S)-2-tert-Butoxycarbonylamino-4-isopropoxycarbonyl-butyrylamino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoic acid benzyl ester → 3-({(S)-1-[3-({(S)-1-[3-((S)-2-tert-Butoxycarbonylamino-4-isopropoxycarbonyl-butyrylamino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoic acid benzyl ester (259665-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / Pd/C / methanol / 2 h / 760 Torr

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium BF₄; N-ethyldiisopropylamine / dimethylformamide / 2 h

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; 1: Catalytic hydrogenation / 2: Acylation;

DOI:10.1021/jo991087d

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → 3-({(S)-1-[3-({(S)-1-[3-((S)-2-tert-Butoxycarbonylamino-4-isopropoxycarbonyl-butyrylamino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoic acid benzyl ester (259665-77-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / chlorotripyrrolidinophosphonium hexafluorophosphate, N-ethyldiisopropylamine / CH₂Cl₂

2: trifluoroacetic acid / CH₂Cl₂ / 1.5 h / 0 - 5 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium BF₄; N-ethyldiisopropylamine / dimethylformamide / 2 h

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; chlorotri(pyrrolidin-1-yl)phosphonium hexafluorophosphate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: Hydrolysis / 3: Acylation;

DOI:10.1021/jo991087d

Reference yield:

3-aminobenzoic acid benzyl ester toluene-4-sulfonate → 3-({(S)-1-[3-({(S)-1-[3-((S)-2-tert-Butoxycarbonylamino-4-isopropoxycarbonyl-butyrylamino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoic acid benzyl ester (259665-77-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / chlorotripyrrolidinophosphonium hexafluorophosphate, N-ethyldiisopropylamine / CH₂Cl₂

2: trifluoroacetic acid / CH₂Cl₂ / 1.5 h / 0 - 5 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium BF₄; N-ethyldiisopropylamine / dimethylformamide / 2 h

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; chlorotri(pyrrolidin-1-yl)phosphonium hexafluorophosphate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: Hydrolysis / 3: Acylation;

DOI:10.1021/jo991087d

upstream raw materials:

3-[((S)-Pyrrolidine-2-carbonyl)-amino]-benzoic acid benzyl ester

1-(tert-butoxycarbonyl)-L-proline

2-(3-benzyloxycarbonyl-phenylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 259665-77-5 3-({(S)-1-[3-({(S)-1-[3-((S)-2-tert-Butoxycarbonylamino-4-isopropoxycarbonyl-butyrylamino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoyl]-pyrrolidine-2-carbonyl}-amino)-benzoic acid benzyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send