1,4-diphenyl-1-pentanone

Base Information

• Chemical Name: 1,4-diphenyl-1-pentanone
• CAS No.: 72256-08-7
• Molecular Formula: C₁₇H₁₈O
• Molecular Weight: 238.329
• Mol file: 72256-08-7.mol

Synonyms:1,4-diphenyl-1-pentanone

Chemical Property of 1,4-diphenyl-1-pentanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-diphenyl-1-pentanone

There total 15 articles about 1,4-diphenyl-1-pentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-phenyl-1-pentanoic acid (16433-43-5) + phenyllithium (591-51-5) → 1,4-diphenyl-1-pentanone (72256-08-7)

Guidance literature:

With lithium hydride; In tetrahydrofuran; diethyl ether; 1.) reflux, 2 h; 2.) 20 deg C, 4 h;

DOI:10.1002/oms.1210150105

Reference yield: 80.0%

1,4-diphenyl-4-penten-1-ol (53910-00-2) → 1,4-diphenyl-1-pentanone (72256-08-7)

Guidance literature:

With 4,5-bis-(di-tert-butyl-phosphanyl)-9,9-dimethyl-9H-xanthene; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; silver carbonate; In toluene; at 50 ℃; for 24h; Inert atmosphere; Glovebox; Molecular sieve;

DOI:10.1021/jacs.8b07007

Reference yield: 70.0%

(Benzoylmethylene)triphenylphosphorane (20913-05-7,859-65-4) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → 1,4-diphenyl-1-pentanone (72256-08-7)

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 10-methyl-9-(2,4,6-trimethylphenyl) acridinium tetrafluoroborate; thiophenol; In dichloromethane; regioselective reaction; Inert atmosphere; Irradiation;

DOI:10.1039/c8sc04195d

upstream raw materials:

4-phenyl-1-pentanoic acid

phenyllithium

1-bromo-2-phenylpropane

ethyl 3-oxo-3-phenylpropionate

Downstream raw materials:

1,4-diphenylbutan-1-one oxime

2,5-diphenyl-1-hexene

(2,2-)-1,4-diphenyl-1-pentanone

Refernces

• 1、 Fu, Haigen,Lam, Heather,Emmanuel, Megan A.,Kim, Ji Hye,Sandoval, Braddock A.,Hyster, Todd K.. "Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C-C Bond Forming Reactions". . p. 9622 - 9629. Retrieved 2021/07/01.
• 2、 Das, Mrinmoy,Vu, Minh Duy,Zhang, Qi,Liu, Xue-Wei. "Metal-free visible light photoredox enables generation of carbyne equivalents via phosphonium ylide C-H activation". . p. 1687 - 1691. Retrieved 2019/02/14.