(3R,4S,5R)-2-Benzyl-5-methyl-3-phenyl-isoxazolidine-4-carboxylic acid methyl ester

Base Information

• Chemical Name: (3R,4S,5R)-2-Benzyl-5-methyl-3-phenyl-isoxazolidine-4-carboxylic acid methyl ester
• CAS No.: 210367-09-2
• Molecular Formula: C₁₉H₂₁NO₃
• Molecular Weight: 311.381
• Mol file: 210367-09-2.mol

Synonyms:(3R,4S,5R)-2-Benzyl-5-methyl-3-phenyl-isoxazolidine-4-carboxylic acid methyl ester

Chemical Property of (3R,4S,5R)-2-Benzyl-5-methyl-3-phenyl-isoxazolidine-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,4S,5R)-2-Benzyl-5-methyl-3-phenyl-isoxazolidine-4-carboxylic acid methyl ester

There total 1 articles about (3R,4S,5R)-2-Benzyl-5-methyl-3-phenyl-isoxazolidine-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methylmagnesium iodide + 2-benzyl-5-methyl-4-(2'-oxo-1',3'-oxazolidine-3'-carbonyl)-3-phenylisoxazolidine (173937-02-5) → (3R,4S,5R)-2-Benzyl-5-methyl-3-phenyl-isoxazolidine-4-carboxylic acid methyl ester (210367-09-2)

Guidance literature:

DOI:10.1021/ja980702c

Reference yield:

(3R,4S,5R)-2-Benzyl-5-methyl-3-phenyl-isoxazolidine-4-carboxylic acid methyl ester (210367-09-2) → (3S,4R)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-phenyl-azetidin-2-one

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / H₂ / Pd/C / 7355.08 Torr

2: 100 percent

3: 78 percent / LDA

With hydrogen; lithium diisopropyl amide; palladium on activated charcoal;

DOI:10.1021/ja980702c

Reference yield:

(3R,4S,5R)-2-Benzyl-5-methyl-3-phenyl-isoxazolidine-4-carboxylic acid methyl ester (210367-09-2) → (2S,3R)-2-((R)-amino-phenyl-methyl)-3-(tert-butyl-dimethyl-silanyloxy)-butyric acid methyl ester (210367-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / H₂ / Pd/C / 7355.08 Torr

2: 100 percent

With hydrogen; palladium on activated charcoal;

DOI:10.1021/ja980702c

upstream raw materials:

2-benzyl-5-methyl-4-(2'-oxo-1',3'-oxazolidine-3'-carbonyl)-3-phenylisoxazolidine

Downstream raw materials:

(2S,3R)-2-((R)-amino-phenyl-methyl)-3-(tert-butyl-dimethyl-silanyloxy)-butyric acid methyl ester