Boc-Ser-OBzl

Base Information

• Chemical Name: Boc-Ser-OBzl
• CAS No.: 87876-51-5
• Molecular Formula: C₅₆H₆₈N₆O₁₂
• Molecular Weight: 1017.19
• Mol file: 87876-51-5.mol

Synonyms:Boc-Ser-OBzl

Chemical Property of Boc-Ser-OBzl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Ser-OBzl

There total 8 articles about Boc-Ser-OBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

Z-D-Abu-Pro-(Me)Phe-Pip-OH (87876-48-0) + Boc-Ser(H-Phg-O)-OBzl*TFA (87876-50-4) → Boc-Ser-OBzl (87876-51-5)

Guidance literature:

With 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In dichloromethane; for 48h; Ambient temperature;

DOI:10.1002/jlac.198319830910

Reference yield:

Boc-N-Me-Phe-OH (37553-65-4) → Boc-Ser-OBzl (87876-51-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 87 percent / N-methylmorpholine, n-propylphosphonic acid anhydride / CH₂Cl₂ / 48 h / Ambient temperature

2: 95 percent / 2N HCl / dioxane / 2 h

3: 37 percent / N-methylmorpholine, n-propylphosphonic acid anhydride / CH₂Cl₂ / 48 h / Ambient temperature

4: 85 percent / 1N NaOH / ethanol / 2 h / Ambient temperature

5: 54 percent / N-methylmorpholine, n-propylphosphonic acid anhydride / CH₂Cl₂ / 48 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In 1,4-dioxane; ethanol; dichloromethane;

DOI:10.1002/jlac.198319830910

Reference yield:

(S)-methyl pipecolinate hydrochloride (18650-39-0) → Boc-Ser-OBzl (87876-51-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 87 percent / N-methylmorpholine, n-propylphosphonic acid anhydride / CH₂Cl₂ / 48 h / Ambient temperature

2: 95 percent / 2N HCl / dioxane / 2 h

3: 37 percent / N-methylmorpholine, n-propylphosphonic acid anhydride / CH₂Cl₂ / 48 h / Ambient temperature

4: 85 percent / 1N NaOH / ethanol / 2 h / Ambient temperature

5: 54 percent / N-methylmorpholine, n-propylphosphonic acid anhydride / CH₂Cl₂ / 48 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In 1,4-dioxane; ethanol; dichloromethane;

DOI:10.1002/jlac.198319830910

upstream raw materials:

Z-D-Abu-Pro-(Me)Phe-Pip-OH

Boc-Ser(H-Phg-O)-OBzl*TFA

Boc-N-Me-Phe-OH

(S)-methyl pipecolinate hydrochloride

Downstream raw materials:

Boc-Ser-OH