1-[2-(5-chloro-2-benzoxazolinone-3-yl)acetyl]-3-phenyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

Base Information

• Chemical Name: 1-[2-(5-chloro-2-benzoxazolinone-3-yl)acetyl]-3-phenyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole
• CAS No.: 1353647-22-9
• Molecular Formula: C₂₅H₂₀ClN₃O₄
• Molecular Weight: 461.904

Synonyms:1-[2-(5-chloro-2-benzoxazolinone-3-yl)acetyl]-3-phenyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

Chemical Property of 1-[2-(5-chloro-2-benzoxazolinone-3-yl)acetyl]-3-phenyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

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Technology Process of 1-[2-(5-chloro-2-benzoxazolinone-3-yl)acetyl]-3-phenyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

There total 3 articles about 1-[2-(5-chloro-2-benzoxazolinone-3-yl)acetyl]-3-phenyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.2%

2-(5-chloro-2(3H)-benzooxazolon-3-yl)acetohydrazide (1092284-61-1) + 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one (959-33-1) → 1-[2-(5-chloro-2-benzoxazolinone-3-yl)acetyl]-3-phenyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole (1353647-22-9)

Guidance literature:

With hydrogenchloride; In propan-1-ol; water; N,N-dimethyl-formamide; for 120h; Reflux;

DOI:10.1016/j.molstruc.2011.08.061

Reference yield:

ethyl 2-[5-chloro-2-oxobenzo[d]oxazole-2(3H)-yl]acetate (29176-91-8) → 1-[2-(5-chloro-2-benzoxazolinone-3-yl)acetyl]-3-phenyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole (1353647-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol

2: hydrogenchloride / propan-1-ol; water; N,N-dimethyl-formamide / 120 h / Reflux

With hydrogenchloride; hydrazine hydrate; In propan-1-ol; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.molstruc.2011.08.061

Reference yield:

5-chloro-2-benzoxazolinone (95-25-0) → 1-[2-(5-chloro-2-benzoxazolinone-3-yl)acetyl]-3-phenyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole (1353647-22-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone

2: hydrazine hydrate / ethanol

3: hydrogenchloride / propan-1-ol; water; N,N-dimethyl-formamide / 120 h / Reflux

With hydrogenchloride; potassium carbonate; hydrazine hydrate; In propan-1-ol; ethanol; water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.molstruc.2011.08.061

upstream raw materials:

ethyl 2-[5-chloro-2-oxobenzo[d]oxazole-2(3H)-yl]acetate

2-(5-chloro-2(3H)-benzooxazolon-3-yl)acetohydrazide

3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one

5-chloro-2-benzoxazolinone

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