(R)-4-(1,3-dioxoisoindolin-2-yl)-2-(N-isopropoxy-4′-methoxybiphenyl-4-ylsulfonamido)butanoic acid

Base Information

Chemical Name:(R)-4-(1,3-dioxoisoindolin-2-yl)-2-(N-isopropoxy-4′-methoxybiphenyl-4-ylsulfonamido)butanoic acid
CAS No.:1061743-30-3
Molecular Formula:C₂₈H₂₈N₂O₈S
Molecular Weight:552.605
Hs Code.:

Synonyms:(R)-4-(1,3-dioxoisoindolin-2-yl)-2-(N-isopropoxy-4′-methoxybiphenyl-4-ylsulfonamido)butanoic acid

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Chemical Property of (R)-4-(1,3-dioxoisoindolin-2-yl)-2-(N-isopropoxy-4′-methoxybiphenyl-4-ylsulfonamido)butanoic acid

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Technology Process of (R)-4-(1,3-dioxoisoindolin-2-yl)-2-(N-isopropoxy-4′-methoxybiphenyl-4-ylsulfonamido)butanoic acid

There total 3 articles about (R)-4-(1,3-dioxoisoindolin-2-yl)-2-(N-isopropoxy-4′-methoxybiphenyl-4-ylsulfonamido)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1061743-28-9
(R)-tert-butyl 4-(1,3-dioxoisoindolin-2-yl)-2-(N-isopropoxy-4′-methoxybiphenyl-4-ylsulfonamido)butanoate

: 1061743-30-3
(R)-4-(1,3-dioxoisoindolin-2-yl)-2-(N-isopropoxy-4′-methoxybiphenyl-4-ylsulfonamido)butanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 5h;
DOI:10.1021/acs.jmedchem.5b00367

Reference yield:

: 1061743-26-7
(S)-tert-butyl 4-(1,3-dioxoisoindolin-2-yl)-2-hydroxybutanoate

: 1061743-30-3
(R)-4-(1,3-dioxoisoindolin-2-yl)-2-(N-isopropoxy-4′-methoxybiphenyl-4-ylsulfonamido)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 5 h / 0 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1: |Mitsunobu Displacement;
DOI:10.1021/acs.jmedchem.5b00367

Reference yield:

: 1061743-00-7
C₁₆H₁₉NO₄S

: 1061743-30-3
(R)-4-(1,3-dioxoisoindolin-2-yl)-2-(N-isopropoxy-4′-methoxybiphenyl-4-ylsulfonamido)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 5 h / 0 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1: |Mitsunobu Displacement;
DOI:10.1021/acs.jmedchem.5b00367