Trifluoro-methanesulfonic acid (4aS,5R,6S,8aS)-6-benzyloxy-5-benzyloxymethyl-2,5,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl ester

Base Information

Chemical Name:Trifluoro-methanesulfonic acid (4aS,5R,6S,8aS)-6-benzyloxy-5-benzyloxymethyl-2,5,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl ester
CAS No.:171925-89-6
Molecular Formula:C₂₉H₃₅F₃O₅S
Molecular Weight:552.655
Hs Code.:

Trifluoro-methanesulfonic acid (4aS,5R,6S,8aS)-6-benzyloxy-5-benzyloxymethyl-2,5,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl ester

Synonyms:Trifluoro-methanesulfonic acid (4aS,5R,6S,8aS)-6-benzyloxy-5-benzyloxymethyl-2,5,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl ester

Suppliers and Price of Trifluoro-methanesulfonic acid (4aS,5R,6S,8aS)-6-benzyloxy-5-benzyloxymethyl-2,5,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Trifluoro-methanesulfonic acid (4aS,5R,6S,8aS)-6-benzyloxy-5-benzyloxymethyl-2,5,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Trifluoro-methanesulfonic acid (4aS,5R,6S,8aS)-6-benzyloxy-5-benzyloxymethyl-2,5,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl ester

There total 5 articles about Trifluoro-methanesulfonic acid (4aS,5R,6S,8aS)-6-benzyloxy-5-benzyloxymethyl-2,5,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: (4aS,5R,6S,8aS)-6-Benzyloxy-5-benzyloxymethyl-2,5,8a-trimethyl-octahydro-naphthalen-1-one

: 171925-89-6
Trifluoro-methanesulfonic acid (4aS,5R,6S,8aS)-6-benzyloxy-5-benzyloxymethyl-2,5,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl ester

Guidance literature:: With 2,6-di-tert-butyl-4-methylpyridine; In dichloromethane; Heating;
DOI:10.1021/jo00130a005

Reference yield:

: 389103-83-7
(4a'R,5'R,8a'S)-5'-(hydroxymethyl)-5',8a'-dimethylhexahydro-2'H-spiro[[1,3]dioxolane-2,1'-naphthalen]-6'(7'H)-one

: 171925-89-6
Trifluoro-methanesulfonic acid (4aS,5R,6S,8aS)-6-benzyloxy-5-benzyloxymethyl-2,5,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / Me₄NBH(OAc)3, AcOH / acetonitrile

2: NaH / tetrahydrofuran

3: 2 N HCl / tetrahydrofuran

4: 1.) KDA, TMSCl, Et₃N, 2.) BTAF, 4 Angstroem MS / 1.) THF, 2.) THF

5: 86 percent / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / Heating

With hydrogenchloride; chloro-trimethyl-silane; 2,6-di-tert-butyl-4-methylpyridine; 4 Angstroem MS; Diethoxy-methyl-(6-amino-hexylaminomethyl)-silan; sodium hydride; acetic acid; triethylamine; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo00130a005

Reference yield:

: 172018-07-4
C₁₁H₁₄O₂C₂H₄OC₂H₆OH₂

: 171925-89-6
Trifluoro-methanesulfonic acid (4aS,5R,6S,8aS)-6-benzyloxy-5-benzyloxymethyl-2,5,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran

2: 2 N HCl / tetrahydrofuran

3: 1.) KDA, TMSCl, Et₃N, 2.) BTAF, 4 Angstroem MS / 1.) THF, 2.) THF

4: 86 percent / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / Heating

With hydrogenchloride; chloro-trimethyl-silane; 2,6-di-tert-butyl-4-methylpyridine; 4 Angstroem MS; Diethoxy-methyl-(6-amino-hexylaminomethyl)-silan; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00130a005