Ethyl (5-oxopiperazin-2-YL)acetate

Base Information

Chemical Name:Ethyl (5-oxopiperazin-2-YL)acetate
CAS No.:257953-75-6
Molecular Formula:C8H14 N2 O3
Molecular Weight:186.211
Hs Code.:
DSSTox Substance ID:DTXSID80578959
Mol file:257953-75-6.mol

Synonyms:257953-75-6;ETHYL (5-OXOPIPERAZIN-2-YL)ACETATE;ethyl 2-(5-oxopiperazin-2-yl)acetate;2-Piperazineaceticacid,5-oxo-,ethylester(9CI);HCGCAXBTRPXGAK-UHFFFAOYSA-;DTXSID80578959;HCGCAXBTRPXGAK-UHFFFAOYSA-N;InChI=1/C8H14N2O3/c1-2-13-8(12)3-6-4-10-7(11)5-9-6/h6,9H,2-5H2,1H3,(H,10,11)

Suppliers and Price of Ethyl (5-oxopiperazin-2-YL)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AccelPharmtech
5-oxo-2-Piperazineaceticacidethylester 97.00%
25G
$ 6000.00

AccelPharmtech
5-oxo-2-Piperazineaceticacidethylester 97.00%
5G
$ 3230.00

AccelPharmtech
5-oxo-2-Piperazineaceticacidethylester 97.00%
1G
$ 1890.00

Total 1 raw suppliers

Chemical Property of Ethyl (5-oxopiperazin-2-YL)acetate

Chemical Property:

PSA：70.92000
LogP:-0.36770
XLogP3:-0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:186.10044231
Heavy Atom Count:13
Complexity:206

Purity/Quality:: 5-oxo-2-Piperazineaceticacidethylester 97.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC1CNC(=O)CN1

Technology Process of Ethyl (5-oxopiperazin-2-YL)acetate

There total 4 articles about Ethyl (5-oxopiperazin-2-YL)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 257953-71-2
ethyl 4-[N-(benzyloxycarbonyl)glycyl]amino-3-oxobutanoate

: 257953-75-6
5(R,S)-(ethoxycarbonyl)methyl-2-oxopiperazine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 45 ℃; under 2327.17 Torr;
DOI:10.1016/S0040-4020(99)00957-6

Reference yield:

: 2566-19-0
CbzGlyGly

: 257953-75-6
5(R,S)-(ethoxycarbonyl)methyl-2-oxopiperazine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 1 h / 20 °C

2: tetrahydrofuran / 18 h / 20 °C

3: 96 percent / H₂ / Pd-C / ethanol / 45 °C / 2327.17 Torr

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; 1: Substitution / 2: Condensation / 3: Catalytic hydrogenation;
DOI:10.1016/S0040-4020(99)00957-6