2-Piperazineaceticacid,5-oxo-,ethylester(9CI)

Base Information

• Chemical Name: 2-Piperazineaceticacid,5-oxo-,ethylester(9CI)
• CAS No.: 257953-75-6
• Molecular Formula: C8H14 N2 O3
• Molecular Weight: 186.211
• Mol file: 257953-75-6.mol

Synonyms:2-Piperazineaceticacid,5-oxo-,ethylester(9CI);ETHYL (5-OXOPIPERAZIN-2-YL)ACETATE

Chemical Property of 2-Piperazineaceticacid,5-oxo-,ethylester(9CI)

Chemical Property:

• PSA: 70.92000
• LogP: -0.36770

Purity/Quality:

5-oxo-2-Piperazineaceticacidethylester 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Piperazineaceticacid,5-oxo-,ethylester(9CI)

There total 4 articles about 2-Piperazineaceticacid,5-oxo-,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 4-[N-(benzyloxycarbonyl)glycyl]amino-3-oxobutanoate (257953-71-2) → 5(R,S)-(ethoxycarbonyl)methyl-2-oxopiperazine (257953-75-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 45 ℃; under 2327.17 Torr;

DOI:10.1016/S0040-4020(99)00957-6

Reference yield:

CbzGlyGly (2566-19-0) → 5(R,S)-(ethoxycarbonyl)methyl-2-oxopiperazine (257953-75-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 1 h / 20 °C

2: tetrahydrofuran / 18 h / 20 °C

3: 96 percent / H₂ / Pd-C / ethanol / 45 °C / 2327.17 Torr

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; 1: Substitution / 2: Condensation / 3: Catalytic hydrogenation;

DOI:10.1016/S0040-4020(99)00957-6

Reference yield:

ethyl (2E)-(5-oxopiperazin-2-ylidene)ethanoate (764698-14-8) → 5(R,S)-(ethoxycarbonyl)methyl-2-oxopiperazine (257953-75-6)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 0 - 20 ℃;

upstream raw materials:

ethyl 4-[N-(benzyloxycarbonyl)glycyl]amino-3-oxobutanoate

CbzGlyGly

ethyl (2E)-(5-oxopiperazin-2-ylidene)ethanoate

Downstream raw materials:

2-(5-oxo-1-tosylpiperazin-2-yl)acetic acid

ethyl 2-(5-oxo-1-tosylpiperazin-2-yl)acetate

ethyl {1-[(3-chlorophenyl)sulfonyl]-5-oxopiperazin-2-yl}acetate

7-phenyl-4-H-tetrahydropyrazino[1,2-f]pyrimidine-3,6,8-trione

Refernces

• 1、 Patino-Molina, Rosario,Herranz, Rosario,Garcia-Lopez, M. Teresa,Gonzalez-Muniz, Rosario. "Stereoselective reductive amination of β-keto esters derived from dipeptides. Stereochemical and mechanistic studies on the formation of 5-carboxymethyl-2-oxopiperazine derivatives". . p. 15001 - 15010. Retrieved 2007/10/03.