tert-butyl 5-{[(2'-cyano-6'-fluorobiphenyl-4-yl)carbonyl] (cyclopropyl)amino}-4,5,6,7-tetrahydro-2H-indazole-2-carboxylate

Base Information

Chemical Name:tert-butyl 5-{[(2'-cyano-6'-fluorobiphenyl-4-yl)carbonyl] (cyclopropyl)amino}-4,5,6,7-tetrahydro-2H-indazole-2-carboxylate
CAS No.:1431307-89-9
Molecular Formula:C₂₉H₂₉FN₄O₃
Molecular Weight:500.573
Hs Code.:

Synonyms:tert-butyl 5-{[(2'-cyano-6'-fluorobiphenyl-4-yl)carbonyl] (cyclopropyl)amino}-4,5,6,7-tetrahydro-2H-indazole-2-carboxylate

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Chemical Property of tert-butyl 5-{[(2'-cyano-6'-fluorobiphenyl-4-yl)carbonyl] (cyclopropyl)amino}-4,5,6,7-tetrahydro-2H-indazole-2-carboxylate

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Technology Process of tert-butyl 5-{[(2'-cyano-6'-fluorobiphenyl-4-yl)carbonyl] (cyclopropyl)amino}-4,5,6,7-tetrahydro-2H-indazole-2-carboxylate

There total 5 articles about tert-butyl 5-{[(2'-cyano-6'-fluorobiphenyl-4-yl)carbonyl] (cyclopropyl)amino}-4,5,6,7-tetrahydro-2H-indazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431311-68-0
tert-butyl 5-(cyclopropylamino)-4,5,6,7-tetrahydro-2H-indazole-2-carboxylate

: C₁₄H₇ClFNO

: 1431307-89-9
tert-butyl 5-{[(2'-cyano-6'-fluorobiphenyl-4-yl)carbonyl] (cyclopropyl)amino}-4,5,6,7-tetrahydro-2H-indazole-2-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 425379-16-4
2-bromo-3-fluorobenzonitrile

: 1431307-89-9
tert-butyl 5-{[(2'-cyano-6'-fluorobiphenyl-4-yl)carbonyl] (cyclopropyl)amino}-4,5,6,7-tetrahydro-2H-indazole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 100 °C / Inert atmosphere

2: water; sodium hydroxide / ethanol / 0.5 h / 70 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1431307-89-9
tert-butyl 5-{[(2'-cyano-6'-fluorobiphenyl-4-yl)carbonyl] (cyclopropyl)amino}-4,5,6,7-tetrahydro-2H-indazole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 100 °C / Inert atmosphere

2: water; sodium hydroxide / ethanol / 0.5 h / 70 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water;