3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester
CAS No.:366793-01-3
Molecular Formula:C₃₂H₄₃N₇O₉
Molecular Weight:669.735
Hs Code.:

3-{benzyloxy-[({[2-(<i>N</i>'-<i>tert</i>-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

Synonyms:3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

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Chemical Property of 3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

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Technology Process of 3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

There total 8 articles about 3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23776-83-2
N'-(2-aminoacetyl)hydrazinecarboxylic acid tert-butyl ester

: 366793-01-3
3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: DCC; DMAP / CH₂Cl₂ / 24 h / 20 °C

2: 100 percent / H₂ / 20percent Pd(OH)2/C / methanol / 8 h / 20 °C

3: BOP-Cl; Et₃N / CH₂Cl₂ / -20 - 0 °C

4: 87 percent / Et₂NH / acetonitrile / 0.33 h / 20 °C

With dmap; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylamine; triethylamine; dicyclohexyl-carbodiimide; 20percent Pd(OH)2/C; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/ol016440s

Reference yield:

: 366792-99-6
N'-{[2-(benzyloxycarbonyl-methyl-amino)-acetylamino]-acetyl}-hydrazinecarboxylic acid tert-butyl ester

: 366793-01-3
3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / 20percent Pd(OH)2/C / methanol / 8 h / 20 °C

2: BOP-Cl; Et₃N / CH₂Cl₂ / -20 - 0 °C

3: 87 percent / Et₂NH / acetonitrile / 0.33 h / 20 °C

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylamine; triethylamine; 20percent Pd(OH)2/C; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/ol016440s

Reference yield:

: 142635-71-0
D-(N^α-Fmoc,N^δ-Cbz)-Piz-Cl

: 366793-01-3
3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: AgCN / benzene / 0.67 h / 70 °C

2: 96 percent / CF₃COOH; PhOH / CH₂Cl₂ / 2 h / 0 °C

3: BOP-Cl; Et₃N / CH₂Cl₂ / -20 - 0 °C

4: 87 percent / Et₂NH / acetonitrile / 0.33 h / 20 °C

With silver cyanide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylamine; triethylamine; trifluoroacetic acid; phenol; In dichloromethane; acetonitrile; benzene;
DOI:10.1021/ol016440s