Carbamic acid, [(1R,2S)-1,2-bis(hydroxymethyl)cyclopropyl]-, 1,1-dimethylethyl

Base Information

Chemical Name:Carbamic acid, [(1R,2S)-1,2-bis(hydroxymethyl)cyclopropyl]-, 1,1-dimethylethyl
CAS No.:257878-00-5
Molecular Formula:C₁₀H₁₉NO₄
Molecular Weight:217.265
Hs Code.:
Mol file:257878-00-5.mol

Synonyms:Carbamic acid, [(1R,2S)-1,2-bis(hydroxymethyl)cyclopropyl]-, 1,1-dimethylethyl

Suppliers and Price of Carbamic acid, [(1R,2S)-1,2-bis(hydroxymethyl)cyclopropyl]-, 1,1-dimethylethyl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [(1R,2S)-1,2-bis(hydroxymethyl)cyclopropyl]-, 1,1-dimethylethyl

Chemical Property:

Boiling Point:361.5±15.0 °C(Predicted)
PKA:11.96±0.40(Predicted)
PSA：78.79000
Density:1.18±0.1 g/cm3(Predicted)
LogP:0.64530

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1R,2S)-1,2-bis(hydroxymethyl)cyclopropyl]-, 1,1-dimethylethyl

There total 6 articles about Carbamic acid, [(1R,2S)-1,2-bis(hydroxymethyl)cyclopropyl]-, 1,1-dimethylethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 257877-95-5
methyl (1R,2S)-(+)-1-N-tert-butoxycarbonylamino-2-hydroxymethylcyclopropanecarboxylate

: 257878-00-5
(1R,2S)-(+)-1-N-tert-butoxycarbonylamino-1,2-bis(hydroxymethyl)cyclopropane

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at -78 - 20 ℃; for 18h;
DOI:10.1016/S0957-4166(99)00463-2

Reference yield:

: 121056-95-9,89524-98-1
trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate

: 257878-00-5
(1R,2S)-(+)-1-N-tert-butoxycarbonylamino-1,2-bis(hydroxymethyl)cyclopropane

Guidance literature:: Multi-step reaction with 6 steps

1.1: 85 percent / t-BuOK

2.2: 87 percent / Irradiation

3.1: 95 percent / HCl

4.1: 85 percent / NaIO₄

5.1: 92 percent / NaBH₄

6.1: 88 percent / LiBH₄ / tetrahydrofuran / 18 h / -78 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; sodium periodate; lithium borohydride; potassium tert-butylate; In tetrahydrofuran; 1.1: Condensation / 2.1: Cycloaddition / 2.2: photolysis / 3.1: Hydrolysis / 4.1: oxidative cleavage / 5.1: Reduction / 6.1: Reduction;
DOI:10.1016/S0957-4166(99)00463-2

Reference yield:

: 257877-99-9
methyl (1R,2S)-(+)-1-N-tert-butoxycarbonylamino-2-formylcyclopropanecarboxylate

: 257878-00-5
(1R,2S)-(+)-1-N-tert-butoxycarbonylamino-1,2-bis(hydroxymethyl)cyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / NaBH₄

2: 88 percent / LiBH₄ / tetrahydrofuran / 18 h / -78 - 20 °C

With sodium tetrahydroborate; lithium borohydride; In tetrahydrofuran; 1: Reduction / 2: Reduction;
DOI:10.1016/S0957-4166(99)00463-2