3α-((dimethylphenylsilyl)oxy)-17-(Z)-ethylidene-6-methylene-5α-androstane

Base Information

Chemical Name:3α-((dimethylphenylsilyl)oxy)-17-(Z)-ethylidene-6-methylene-5α-androstane
CAS No.:226714-54-1
Molecular Formula:C₃₀H₄₄OSi
Molecular Weight:448.764
Hs Code.:

Synonyms:3α-((dimethylphenylsilyl)oxy)-17-(Z)-ethylidene-6-methylene-5α-androstane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3α-((dimethylphenylsilyl)oxy)-17-(Z)-ethylidene-6-methylene-5α-androstane

Chemical Property:

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Technology Process of 3α-((dimethylphenylsilyl)oxy)-17-(Z)-ethylidene-6-methylene-5α-androstane

There total 3 articles about 3α-((dimethylphenylsilyl)oxy)-17-(Z)-ethylidene-6-methylene-5α-androstane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 768-33-2
phenyldimethylsilyl chloride

: 226714-58-5
17-(Z)-ethylidene-3α-hydroxy-6-methylene-5α-androstane

: 226714-54-1
3α-((dimethylphenylsilyl)oxy)-17-(Z)-ethylidene-6-methylene-5α-androstane

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 2.5h;
DOI:10.1021/ja9808595

Reference yield:

: 53512-53-1
3α-hydroxy-5α-androstane-6,17-dione

: 226714-54-1
3α-((dimethylphenylsilyl)oxy)-17-(Z)-ethylidene-6-methylene-5α-androstane

Guidance literature:: Multi-step reaction with 3 steps

1: 39 percent / potassium tert-butoxide / tetrahydrofuran / 3 h / -60 °C

2: 59 percent / potassium tert-butoxide / tetrahydrofuran / 4.5 h / Ambient temperature

3: 47 percent / triethylamine / dimethylformamide / 2.5 h

With potassium tert-butylate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja9808595

Reference yield:

: 226714-56-3
3α-hydroxy-6-methylene-5α-androstan-17-one

: 226714-54-1
3α-((dimethylphenylsilyl)oxy)-17-(Z)-ethylidene-6-methylene-5α-androstane

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / potassium tert-butoxide / tetrahydrofuran / 4.5 h / Ambient temperature

2: 47 percent / triethylamine / dimethylformamide / 2.5 h

With potassium tert-butylate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja9808595