N-({trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-cyclobutyl}methyl)-N-methylacetamide hydrochloroic acid

Base Information

Chemical Name:N-({trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-cyclobutyl}methyl)-N-methylacetamide hydrochloroic acid
CAS No.:1337536-82-9
Molecular Formula:C₁₉H₂₇ClN₂O*ClH
Molecular Weight:371.35
Hs Code.:

Synonyms:N-({trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-cyclobutyl}methyl)-N-methylacetamide hydrochloroic acid

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Chemical Property of N-({trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-cyclobutyl}methyl)-N-methylacetamide hydrochloroic acid

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Technology Process of N-({trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-cyclobutyl}methyl)-N-methylacetamide hydrochloroic acid

There total 9 articles about N-({trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-cyclobutyl}methyl)-N-methylacetamide hydrochloroic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1337536-66-9
N-({trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-cyclobutyl}methyl)-N-methylacetamide

: 1337536-82-9
N-({trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-cyclobutyl}methyl)-N-methylacetamide hydrochloroic acid

Guidance literature:: With hydrogenchloride; In diethyl ether; ethyl acetate;
DOI:10.1021/jm200939b

Reference yield:

: 935839-86-4
trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-methylcyclobutanecarboxamide

: 1337536-82-9
N-({trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-cyclobutyl}methyl)-N-methylacetamide hydrochloroic acid

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / 16 h / 70 °C

2: triethylamine / dichloromethane / 0.5 h / 0 °C

3: hydrogenchloride / diethyl ether; ethyl acetate

With hydrogenchloride; borane-THF; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jm200939b

Reference yield:

: 1337536-68-1
1-{trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-cyclobutyl}-N-methylmethanamine

: 1337536-82-9
N-({trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-cyclobutyl}methyl)-N-methylacetamide hydrochloroic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.5 h / 0 °C

2: hydrogenchloride / diethyl ether; ethyl acetate

With hydrogenchloride; triethylamine; In diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jm200939b