2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-thiopyran-4-yl]-benzenesufonamide

Base Information

Chemical Name:2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-thiopyran-4-yl]-benzenesufonamide
CAS No.:928851-52-9
Molecular Formula:C₂₈H₃₂Cl₂N₄O₄S₂
Molecular Weight:623.624
Hs Code.:

Synonyms:2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-thiopyran-4-yl]-benzenesufonamide

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Chemical Property of 2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-thiopyran-4-yl]-benzenesufonamide

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Technology Process of 2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-thiopyran-4-yl]-benzenesufonamide

There total 5 articles about 2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-thiopyran-4-yl]-benzenesufonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 928851-59-6
4-{4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-thiopyran-4-carbonyl}-piperazine-1-carboxylic acid tert-butyl ester

: 928851-52-9
2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-thiopyran-4-yl]-benzenesufonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm061143k

Reference yield:

: 188440-21-3
3-bromomethyl-2,4-dichlorobenzenesulphonyl chloride

: 928851-52-9
2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-thiopyran-4-yl]-benzenesufonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. NaHCO₃ / acetonitrile / 19.5 h / 20 °C

1.2: dimethylformamide / 20 °C

2.1: aq. NaOH / dioxane / 100 °C

3.1: diisopropylethylamine; (benzotriazol-1-yloxy)tripyrrolidinophosphonium*PF₆ / dimethylformamide

4.1: trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

With sodium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm061143k

Reference yield:

: 1026722-01-9
4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-thiopyran-4-carboxylic acid methyl ester

: 928851-52-9
2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-thiopyran-4-yl]-benzenesufonamide

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH / dioxane / 100 °C

2: diisopropylethylamine; (benzotriazol-1-yloxy)tripyrrolidinophosphonium*PF₆ / dimethylformamide

3: trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

With sodium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm061143k