3-[methyl[4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]amino)cyclohexyl]amino]propanoic acid

Base Information

• Chemical Name: 3-[methyl[4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]amino)cyclohexyl]amino]propanoic acid
• CAS No.: 1388891-03-9
• Molecular Formula: C₁₉H₂₆N₄O₂S
• Molecular Weight: 374.507

Synonyms:3-[methyl[4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]amino)cyclohexyl]amino]propanoic acid

Chemical Property of 3-[methyl[4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]amino)cyclohexyl]amino]propanoic acid

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Technology Process of 3-[methyl[4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]amino)cyclohexyl]amino]propanoic acid

There total 4 articles about 3-[methyl[4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]amino)cyclohexyl]amino]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-[methyl[4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-12-yl]amino)cyclohexyl]amino]propanoate (1388891-05-1) → 3-[methyl[4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-12-yl]amino)cyclohexyl]amino]propanoic acid (1388891-03-9)

Guidance literature:

methyl 3-[methyl[4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]amino)cyclohexyl]amino]propanoate; With water; sodium hydroxide; In methanol; at 50 ℃;

With hydrogenchloride; In water; pH=1 - 2;

Reference yield:

trans-1,4-cyclohexyldiamine (2615-25-0) → 3-[methyl[4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-12-yl]amino)cyclohexyl]amino]propanoic acid (1388891-03-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Reflux

4.1: methanol / Reflux

5.1: sodium hydroxide; water / methanol / 50 °C

5.2: pH 1 - 2

With lithium aluminium tetrahydride; water; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine (300816-22-2) → 3-[methyl[4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1(8),2(6),9,11-tetraen-12-yl]amino)cyclohexyl]amino]propanoic acid (1388891-03-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Reflux

4.1: methanol / Reflux

5.1: sodium hydroxide; water / methanol / 50 °C

5.2: pH 1 - 2

With lithium aluminium tetrahydride; water; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

upstream raw materials:

4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine

trans-1,4-cyclohexyldiamine

methyl 3-[methyl[4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]amino)cyclohexyl]amino]propanoate

trans-N₁-(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)-N₄-methylcyclohexane-1,4-diamine

Downstream raw materials:

3-[methyl[4-([7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yl]amino)cyclohexyl]amino]propanamide

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