tert-butyl 4-(2-(3-(tert-butyl)-4-(cyclopentylamino)phenyl)pyrimidin-4-yl)piperazine-1-carboxylate

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Chemical Name:tert-butyl 4-(2-(3-(tert-butyl)-4-(cyclopentylamino)phenyl)pyrimidin-4-yl)piperazine-1-carboxylate
CAS No.:1378368-15-0
Molecular Formula:C₂₈H₄₁N₅O₂
Molecular Weight:479.666
Hs Code.:

Synonyms:tert-butyl 4-(2-(3-(tert-butyl)-4-(cyclopentylamino)phenyl)pyrimidin-4-yl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-(3-(tert-butyl)-4-(cyclopentylamino)phenyl)pyrimidin-4-yl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(2-(3-(tert-butyl)-4-(cyclopentylamino)phenyl)pyrimidin-4-yl)piperazine-1-carboxylate

There total 5 articles about tert-butyl 4-(2-(3-(tert-butyl)-4-(cyclopentylamino)phenyl)pyrimidin-4-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 221050-88-0
4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester

: 1378368-13-8
2-(tert-butyl)-N-cyclopentyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

: 1378368-15-0
tert-butyl 4-(2-(3-(tert-butyl)-4-(cyclopentylamino)phenyl)pyrimidin-4-yl)piperazine-1-carboxylate

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 80 ℃; for 16h; Inert atmosphere;

Reference yield:

: 120-92-3
cyclopentanone

: 1378368-15-0
tert-butyl 4-(2-(3-(tert-butyl)-4-(cyclopentylamino)phenyl)pyrimidin-4-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0.17 h / 140 °C / microwave irradiation

2: tetra-N-butylammonium tribromide / tetrahydrofuran / 0 - 20 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

4: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

With potassium acetate; tetra-N-butylammonium tribromide; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 6310-21-0
2-(1,1-dimethylethyl)-benzenamine

: 1378368-15-0
tert-butyl 4-(2-(3-(tert-butyl)-4-(cyclopentylamino)phenyl)pyrimidin-4-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0.17 h / 140 °C / microwave irradiation

2: tetra-N-butylammonium tribromide / tetrahydrofuran / 0 - 20 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

4: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

With potassium acetate; tetra-N-butylammonium tribromide; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide;