3-[7-Chloro-2-(4-methoxy-benzyl)-3-methyl-4-(1-methyl-1-trimethylsilanyl-ethoxy)-benzofuran-5-yl]-propan-1-ol

Base Information

• Chemical Name: 3-[7-Chloro-2-(4-methoxy-benzyl)-3-methyl-4-(1-methyl-1-trimethylsilanyl-ethoxy)-benzofuran-5-yl]-propan-1-ol
• CAS No.: 120034-24-4
• Molecular Formula: C₂₆H₃₅ClO₄Si
• Molecular Weight: 475.1
• Mol file: 120034-24-4.mol

Synonyms:3-[7-Chloro-2-(4-methoxy-benzyl)-3-methyl-4-(1-methyl-1-trimethylsilanyl-ethoxy)-benzofuran-5-yl]-propan-1-ol

Chemical Property of 3-[7-Chloro-2-(4-methoxy-benzyl)-3-methyl-4-(1-methyl-1-trimethylsilanyl-ethoxy)-benzofuran-5-yl]-propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[7-Chloro-2-(4-methoxy-benzyl)-3-methyl-4-(1-methyl-1-trimethylsilanyl-ethoxy)-benzofuran-5-yl]-propan-1-ol

There total 8 articles about 3-[7-Chloro-2-(4-methoxy-benzyl)-3-methyl-4-(1-methyl-1-trimethylsilanyl-ethoxy)-benzofuran-5-yl]-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-5-tert-butyl-2,6-dihydroxyacetophenone (120034-10-8) → 3-[7-Chloro-2-(4-methoxy-benzyl)-3-methyl-4-(1-methyl-1-trimethylsilanyl-ethoxy)-benzofuran-5-yl]-propan-1-ol (120034-24-4)

Guidance literature:

Multi-step reaction with 7 steps

2: 81 percent / ZnI₂, NaCNBH₄ / 1,2-dichloro-ethane / 6 h / Heating

3: 58 percent / AlCl₃ / CH₂Cl₂; various solvent(s) / 1 h / 0 °C

4: 1.94 g / K₂CO₃ / acetone / 20 h / Heating

5: 1.5 g / various solvent(s) / 6 h / Heating

6: 410 mg / Et₃N, (dimethylamino)pyridine / CH₂Cl₂ / 20 h / Ambient temperature

7: 1.) BH₃, 2.) trimethylamine N-oxide / 1.a) THF, -78 deg C, 1 h, b) r.t., 1 h, 2.) reflux, 3 h

With dmap; aluminium trichloride; trimethylamine-N-oxide; borane; sodium cyanoborohydride; potassium carbonate; triethylamine; zinc(II) iodide; In dichloromethane; 1,2-dichloro-ethane; acetone;

DOI:10.1021/jm00126a008

Reference yield:

4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran (120034-16-4) → 3-[7-Chloro-2-(4-methoxy-benzyl)-3-methyl-4-(1-methyl-1-trimethylsilanyl-ethoxy)-benzofuran-5-yl]-propan-1-ol (120034-24-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.94 g / K₂CO₃ / acetone / 20 h / Heating

2: 1.5 g / various solvent(s) / 6 h / Heating

3: 410 mg / Et₃N, (dimethylamino)pyridine / CH₂Cl₂ / 20 h / Ambient temperature

4: 1.) BH₃, 2.) trimethylamine N-oxide / 1.a) THF, -78 deg C, 1 h, b) r.t., 1 h, 2.) reflux, 3 h

With dmap; trimethylamine-N-oxide; borane; potassium carbonate; triethylamine; In dichloromethane; acetone;

DOI:10.1021/jm00126a008

Reference yield:

5-allyl-4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran (120034-18-6) → 3-[7-Chloro-2-(4-methoxy-benzyl)-3-methyl-4-(1-methyl-1-trimethylsilanyl-ethoxy)-benzofuran-5-yl]-propan-1-ol (120034-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 410 mg / Et₃N, (dimethylamino)pyridine / CH₂Cl₂ / 20 h / Ambient temperature

2: 1.) BH₃, 2.) trimethylamine N-oxide / 1.a) THF, -78 deg C, 1 h, b) r.t., 1 h, 2.) reflux, 3 h

With dmap; trimethylamine-N-oxide; borane; triethylamine; In dichloromethane;

DOI:10.1021/jm00126a008

upstream raw materials:

{1-[5-Allyl-7-chloro-2-(4-methoxy-benzyl)-3-methyl-benzofuran-4-yloxy]-1-methyl-ethyl}-trimethyl-silane

3-chloro-5-tert-butyl-2,6-dihydroxyacetophenone

4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

5-allyl-4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

Downstream raw materials:

4-hydroxy-5-(carboxyethyl)-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

3-[7-Chloro-2-(4-methoxy-benzyl)-3-methyl-4-(1-methyl-1-trimethylsilanyl-ethoxy)-benzofuran-5-yl]-propionic acid

4-hydroxy-5-(hydroxypropyl)-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran