3-fluoro-4-[5-fluoro-7-[1-(5-propyl-[1,2,4]oxadiazol-3-yl)piperidin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide

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Chemical Name:3-fluoro-4-[5-fluoro-7-[1-(5-propyl-[1,2,4]oxadiazol-3-yl)piperidin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide
CAS No.:1236282-41-9
Molecular Formula:C₂₅H₂₈F₂N₈O₂
Molecular Weight:510.547
Hs Code.:

Synonyms:3-fluoro-4-[5-fluoro-7-[1-(5-propyl-[1,2,4]oxadiazol-3-yl)piperidin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide

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Chemical Property of 3-fluoro-4-[5-fluoro-7-[1-(5-propyl-[1,2,4]oxadiazol-3-yl)piperidin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide

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Technology Process of 3-fluoro-4-[5-fluoro-7-[1-(5-propyl-[1,2,4]oxadiazol-3-yl)piperidin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide

There total 2 articles about 3-fluoro-4-[5-fluoro-7-[1-(5-propyl-[1,2,4]oxadiazol-3-yl)piperidin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1236284-90-4
3-fluoro-4-[5-fluoro-7-[1-(N-hydroxycarbamimidoyl)piperidin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide

: 141-75-3
butyryl chloride

: 1236282-41-9
3-fluoro-4-[5-fluoro-7-[1-(5-propyl-[1,2,4]oxadiazol-3-yl)piperidin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide

Guidance literature:: With triethylamine; In toluene; at 130 ℃; for 2h; Cooling with ice;

Reference yield:

: 1236347-38-8
3-fluoro-4-[5-fluoro-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide

: 1236282-41-9
3-fluoro-4-[5-fluoro-7-[1-(5-propyl-[1,2,4]oxadiazol-3-yl)piperidin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / ethanol; tetrahydrofuran / 16 h / 20 °C

2: hydroxylamine / isopropyl alcohol; water / 4 h / 90 °C

3: triethylamine / toluene / 2 h / 130 °C / Cooling with ice

With hydroxylamine; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; ethanol; water; isopropyl alcohol; toluene;