4-[(3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy]-2-(2-methylprop-2-enyl)phenol

Base Information

Chemical Name:4-[(3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy]-2-(2-methylprop-2-enyl)phenol
CAS No.:451456-51-2
Molecular Formula:C₁₆H₁₃ClF₃NO₂
Molecular Weight:343.733
Hs Code.:

Synonyms:4-[(3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy]-2-(2-methylprop-2-enyl)phenol

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Chemical Property of 4-[(3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy]-2-(2-methylprop-2-enyl)phenol

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Technology Process of 4-[(3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy]-2-(2-methylprop-2-enyl)phenol

There total 4 articles about 4-[(3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy]-2-(2-methylprop-2-enyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 451456-49-8
3-chloro-2-[4-(2-methylprop-2-enyloxy)phenoxy]-5-(trifluoromethyl)pyridine

: 451456-51-2
4-[(3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy]-2-(2-methylprop-2-enyl)phenol

Guidance literature:: With N,N-diethylaniline; at 210 - 215 ℃; for 3.5h;
DOI:10.1021/jf0116395

Reference yield:

: 69045-89-2
2-(4'-hydroxyphenoxy)-3-chloro-5-trifluoromethylpyridine

: 451456-51-2
4-[(3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy]-2-(2-methylprop-2-enyl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylsulfoxide / 4 h / 80 - 85 °C

2: 73 percent / PhNEt₂ / 3.5 h / 210 - 215 °C

With potassium carbonate; N,N-diethylaniline; In dimethyl sulfoxide; 2: Claisen rearrangement;
DOI:10.1021/jf0116395

Reference yield:

: 123-31-9,8027-02-9
hydroquinone

: 451456-51-2
4-[(3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy]-2-(2-methylprop-2-enyl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / aq. NaOH / dimethylsulfoxide

2: K₂CO₃ / dimethylsulfoxide / 4 h / 80 - 85 °C

3: 73 percent / PhNEt₂ / 3.5 h / 210 - 215 °C

With sodium hydroxide; potassium carbonate; N,N-diethylaniline; In dimethyl sulfoxide; 3: Claisen rearrangement;
DOI:10.1021/jf0116395