5-[3-chloro-5-(2,2,2-trifluoro-1,1-dimethylethoxymethyl)phenyl]-1-phenyl-1H-pyrazol-3-ylamine

Base Information

Chemical Name:5-[3-chloro-5-(2,2,2-trifluoro-1,1-dimethylethoxymethyl)phenyl]-1-phenyl-1H-pyrazol-3-ylamine
CAS No.:1426408-91-4
Molecular Formula:C₂₀H₁₉ClF₃N₃O
Molecular Weight:409.839
Hs Code.:

Synonyms:5-[3-chloro-5-(2,2,2-trifluoro-1,1-dimethylethoxymethyl)phenyl]-1-phenyl-1H-pyrazol-3-ylamine

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Chemical Property of 5-[3-chloro-5-(2,2,2-trifluoro-1,1-dimethylethoxymethyl)phenyl]-1-phenyl-1H-pyrazol-3-ylamine

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Technology Process of 5-[3-chloro-5-(2,2,2-trifluoro-1,1-dimethylethoxymethyl)phenyl]-1-phenyl-1H-pyrazol-3-ylamine

There total 7 articles about 5-[3-chloro-5-(2,2,2-trifluoro-1,1-dimethylethoxymethyl)phenyl]-1-phenyl-1H-pyrazol-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426408-90-3
2-[3-chloro-5-(2,2,2-trifluoro-1,1-dimethylethoxymethyl)phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 1426408-41-4
5-iodo-1-phenyl-1H-pyrazol-3-ylamine

: 1426408-91-4
5-[3-chloro-5-(2,2,2-trifluoro-1,1-dimethylethoxymethyl)phenyl]-1-phenyl-1H-pyrazol-3-ylamine

Guidance literature:: With palladium diacetate; sodium carbonate; tricyclohexylphosphine; In 1,2-dimethoxyethane; water; at 100 ℃; for 13h; Inert atmosphere;

Reference yield:

: 1128-56-9
3-amino-1-phenylpyrazole

: 1426408-91-4
5-[3-chloro-5-(2,2,2-trifluoro-1,1-dimethylethoxymethyl)phenyl]-1-phenyl-1H-pyrazol-3-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 3 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.08 h / -78 °C

2.2: 1.67 h / -78 °C

2.3: 1 h / -78 - 20 °C

3.1: hydroxylamine hydrochloride; triethylamine / water; ethanol / 72 h / 95 °C

4.1: sodium carbonate; tricyclohexylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 13 h / 100 °C / Inert atmosphere

With n-butyllithium; hydroxylamine hydrochloride; palladium diacetate; sodium carbonate; acetic acid; triethylamine; tricyclohexylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; hexane; water;

Reference yield:

: 1426408-40-3
3-(2,5-dimethylpyrrol-1-yl)-5-iodo-1-phenyl-1H-pyrazole

: 1426408-91-4
5-[3-chloro-5-(2,2,2-trifluoro-1,1-dimethylethoxymethyl)phenyl]-1-phenyl-1H-pyrazol-3-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; triethylamine / water; ethanol / 72 h / 95 °C

2: sodium carbonate; tricyclohexylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 13 h / 100 °C / Inert atmosphere

With hydroxylamine hydrochloride; palladium diacetate; sodium carbonate; triethylamine; tricyclohexylphosphine; In 1,2-dimethoxyethane; ethanol; water;