(4R,5R)-[5-(4-NITROPHENYL)-2-PHENYL-4,5-DIHYDRO-OXAZOL-4-YL]METHANOL

Base Information

• Chemical Name: (4R,5R)-[5-(4-NITROPHENYL)-2-PHENYL-4,5-DIHYDRO-OXAZOL-4-YL]METHANOL
• CAS No.: 256475-85-1
• Molecular Formula: C₁₆H₁₄N₂O₄
• Molecular Weight: 298.298
• Mol file: 256475-85-1.mol

Synonyms:(4R,5R)-[5-(4-NITROPHENYL)-2-PHENYL-4,5-DIHYDRO-OXAZOL-4-YL]METHANOL

Chemical Property of (4R,5R)-[5-(4-NITROPHENYL)-2-PHENYL-4,5-DIHYDRO-OXAZOL-4-YL]METHANOL

Chemical Property:

• Boiling Point: 512.5±45.0 °C(Predicted)
• PKA: 14.22±0.10(Predicted)
• PSA: 87.64000
• Density: 1.36±0.1 g/cm3(Predicted)
• LogP: 2.43260
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

((4R,5R)-5-(4-Nitrophenyl)-2-phenyl-4,5-dihydrooxazol-4-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4R,5R)-[5-(4-NITROPHENYL)-2-PHENYL-4,5-DIHYDRO-OXAZOL-4-YL]METHANOL

There total 16 articles about (4R,5R)-[5-(4-NITROPHENYL)-2-PHENYL-4,5-DIHYDRO-OXAZOL-4-YL]METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3S)-2-benzoylamino-3-methanesulfonyloxy-3-(4-nitro-phenyl)-propan-1-ol → [(4S)-5c-(4-nitro-phenyl)-2-phenyl-4,5-dihydro-oxazol-4-yl]-methanol (132515-24-3,256475-85-1)

Guidance literature:

With ethanol; potassium acetate;

DOI:10.1021/ja01635a078

Reference yield:

(1S,2S)-2-benzoylamino-3-benzoyloxy-1-methanesulfonyloxy-1-(4-nitro-phenyl)-propane → [(4S)-5c-(4-nitro-phenyl)-2-phenyl-4,5-dihydro-oxazol-4-yl]-methanol (132515-24-3,256475-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous methanol.NaOH

2: potassium acetate; ethanol

With sodium hydroxide; ethanol; potassium acetate;

DOI:10.1021/ja01635a078

Reference yield:

(1S,2S)-2-benzoylamino-3-benzoyloxy-1-(4-nitro-phenyl)-propan-1-ol (116181-52-3) → [(4S)-5c-(4-nitro-phenyl)-2-phenyl-4,5-dihydro-oxazol-4-yl]-methanol (132515-24-3,256475-85-1)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: aqueous methanol.NaOH

3: potassium acetate; ethanol

With pyridine; sodium hydroxide; ethanol; potassium acetate;

DOI:10.1021/ja01635a078

upstream raw materials:

(1R,2S)-2-benzoylamino-1-(4-nitro-phenyl)-propane-1,3-diol

(4S)-4r-benzoyloximethyl-5t-(4-nitro-phenyl)-2-phenyl-4,5-dihydro-oxazole

(1R,2S)-1,3-diacetoxy-2-benzoylamino-1-(4-nitro-phenyl)-propane

(1S,2S)-3-acetoxy-2-acetylamino-1-(4-nitro-phenyl)-propan-1-ol

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