(1R,5S,8S,12R)-5-((tert-butyldiphenylsilyloxy)methyl)-12-cyano-6-aza-7-oxatricyclo[6.3.1.0(1,6)]dodecane

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Chemical Name:(1R,5S,8S,12R)-5-((tert-butyldiphenylsilyloxy)methyl)-12-cyano-6-aza-7-oxatricyclo[6.3.1.0(1,6)]dodecane
CAS No.:1063674-45-2
Molecular Formula:C₂₈H₃₆N₂O₂Si
Molecular Weight:460.692
Hs Code.:

Synonyms:(1R,5S,8S,12R)-5-((tert-butyldiphenylsilyloxy)methyl)-12-cyano-6-aza-7-oxatricyclo[6.3.1.0(1,6)]dodecane

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Chemical Property of (1R,5S,8S,12R)-5-((tert-butyldiphenylsilyloxy)methyl)-12-cyano-6-aza-7-oxatricyclo[6.3.1.0(1,6)]dodecane

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Technology Process of (1R,5S,8S,12R)-5-((tert-butyldiphenylsilyloxy)methyl)-12-cyano-6-aza-7-oxatricyclo[6.3.1.0(1,6)]dodecane

There total 1 articles about (1R,5S,8S,12R)-5-((tert-butyldiphenylsilyloxy)methyl)-12-cyano-6-aza-7-oxatricyclo[6.3.1.0(1,6)]dodecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1063674-42-9
(2S,6S,8R)-2-((tert-butyldiphenylsilyloxy)methyl)-6-(5'-cyanopent-4'-en-1'-yl)-8-phenyl-1-aza-9-oxabicyclo[4.3.0]nonane

: 1063674-45-2
(1R,5S,8S,12R)-5-((tert-butyldiphenylsilyloxy)methyl)-12-cyano-6-aza-7-oxatricyclo[6.3.1.0(1,6)]dodecane

Guidance literature:: In ethanol; toluene; at 184 ℃; for 0.833333h; under 9000.9 Torr; diastereoselective reaction; Microwave irradiation;
DOI:10.1021/ol801604z

Reference yield:

: 1063674-45-2
(1R,5S,8S,12R)-5-((tert-butyldiphenylsilyloxy)methyl)-12-cyano-6-aza-7-oxatricyclo[6.3.1.0(1,6)]dodecane

: 1063674-66-7
C₂₈H₃₇NO₃Si

Guidance literature:: (1R,5S,8S,12R)-5-((tert-butyldiphenylsilyloxy)methyl)-12-cyano-6-aza-7-oxatricyclo[6.3.1.0(1,6)]dodecane; With diisobutylaluminium hydride; In toluene; at -78 ℃; for 3.5h;

With hydrogenchloride; methanol; water; rochelle salt; In ethyl acetate; toluene; at -78 - 20 ℃;
DOI:10.1021/ol801604z