methyl (2S)-2-(N-{3-[2-(3-hydroxyprop-1-yn-1-yl)phenyl]prop-2-yn-1-yl}(4-methylbenzene)sulfonamido)-3-methylbutanoate

Base Information

Chemical Name:methyl (2S)-2-(N-{3-[2-(3-hydroxyprop-1-yn-1-yl)phenyl]prop-2-yn-1-yl}(4-methylbenzene)sulfonamido)-3-methylbutanoate
CAS No.:1362825-44-2
Molecular Formula:C₂₅H₂₇NO₅S
Molecular Weight:453.559
Hs Code.:

Synonyms:methyl (2S)-2-(N-{3-[2-(3-hydroxyprop-1-yn-1-yl)phenyl]prop-2-yn-1-yl}(4-methylbenzene)sulfonamido)-3-methylbutanoate

Suppliers and Price of methyl (2S)-2-(N-{3-[2-(3-hydroxyprop-1-yn-1-yl)phenyl]prop-2-yn-1-yl}(4-methylbenzene)sulfonamido)-3-methylbutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (2S)-2-(N-{3-[2-(3-hydroxyprop-1-yn-1-yl)phenyl]prop-2-yn-1-yl}(4-methylbenzene)sulfonamido)-3-methylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (2S)-2-(N-{3-[2-(3-hydroxyprop-1-yn-1-yl)phenyl]prop-2-yn-1-yl}(4-methylbenzene)sulfonamido)-3-methylbutanoate

There total 3 articles about methyl (2S)-2-(N-{3-[2-(3-hydroxyprop-1-yn-1-yl)phenyl]prop-2-yn-1-yl}(4-methylbenzene)sulfonamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1362825-41-9
methyl (2S)-2-{N-[3-(2-iodophenyl)prop-2-yn-1-yl](4-methylbenzene)sulfonamido}-3-methylbutanoate

: 107-19-7
propargyl alcohol

: 1362825-44-2
methyl (2S)-2-(N-{3-[2-(3-hydroxyprop-1-yn-1-yl)phenyl]prop-2-yn-1-yl}(4-methylbenzene)sulfonamido)-3-methylbutanoate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; In tetrahydrofuran; at 40 ℃; for 4.75h; Inert atmosphere;
DOI:10.1021/jo202580y

Reference yield:

: 1253043-95-6
1-iodo-2-(3-iodoprop-1-ynyl)benzene

: 1362825-44-2
methyl (2S)-2-(N-{3-[2-(3-hydroxyprop-1-yn-1-yl)phenyl]prop-2-yn-1-yl}(4-methylbenzene)sulfonamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine / tetrahydrofuran / 4.75 h / 40 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo202580y

Reference yield:

: 51220-85-0,21957-66-4
Methyl (S)-N-<(4-methylphenyl)sulfonyl>valinate

: 1362825-44-2
methyl (2S)-2-(N-{3-[2-(3-hydroxyprop-1-yn-1-yl)phenyl]prop-2-yn-1-yl}(4-methylbenzene)sulfonamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine / tetrahydrofuran / 4.75 h / 40 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo202580y