Technology Process of 3-(cyclohexa-1,4-dien-1-yl)propan-1-amine
There total 2 articles about 3-(cyclohexa-1,4-dien-1-yl)propan-1-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonia; lithium; ammonium chloride;
In
ethanol;
at -78 ℃;
for 1h;
Inert atmosphere;
- Guidance literature:
-
3-Phenylpropylamin, Li, EtOH, fl.NH3;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 62 g / pyridine / 18 h / Ambient temperature
2: 76 percent / H2 / tris(triphenylphosphine)rhodium(I) chloride / tetrahydrofuran / 24 h / 760 Torr
3: 60 percent / m-chloroperbenzoic aicd / CH2Cl2 / 18 h / Ambient temperature
4: 70 percent / BF3*Et2O / CH2Cl2 / a) -78 deg C, 3.5 h, b) -78 deg C to r.t.
5: 100 percent / pyridinium chlorochromate / CH2Cl2 / 18 h
6: 89 percent / pyridine / 18 h
7: 1.3 g / LAH / tetrahydrofuran / 5 h / Ambient temperature
8: 97 percent / Et3N / CH2Cl2 / 1 h / Ambient temperature
9: 78 percent / LAH / tetrahydrofuran / 1.5 h / Ambient temperature
10: 81 percent / Et3N / CH2Cl2 / 1 h
With
pyridine; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate;
Wilkinson's catalyst;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00126a019
