Ethyl 2-hydrazinyl-2-oxoacetate

Base Information

• Chemical Name: Ethyl 2-hydrazinyl-2-oxoacetate
• CAS No.: 35196-48-6
• Molecular Formula: C4H8 N2 O3
• Molecular Weight: 132.119
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID30383050
• Wikidata: Q72471144
• Mol file: 35196-48-6.mol

Synonyms:ethyl 2-hydrazinyl-2-oxoacetate;35196-48-6;ethyl (hydrazinecarbonyl)formate;Ethyl hydrazino(oxo)acetate;MFCD05665958;Ethyl 2-Hydrazino-2-oxoacetate;ethyl2-hydrazinyl-2-oxoacetate;SCHEMBL1653979;SCHEMBL14345063;DTXSID30383050;KGGHFXZJDYAHAE-UHFFFAOYSA-N;hydrazino-oxo-acetic acid ethyl ester;AKOS006228287;CS-W018576;GS-2035;SY034737;Ethanedioic acid 1-ethyl ester 2-hydrazide;Ethanedioic acid, monoethyl ester, hydrazide;EN300-94516;A855520

Chemical Property of Ethyl 2-hydrazinyl-2-oxoacetate

Chemical Property:

• Melting Point: 50-52℃
• PKA: 10.52±0.20(Predicted)
• PSA: 81.42000
• Density: 1.227
• LogP: -0.36940
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 132.05349212
• Heavy Atom Count: 9
• Complexity: 123

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-Hydrazinyl-2-oxoacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(=O)NN

Technology Process of Ethyl 2-hydrazinyl-2-oxoacetate

There total 1 articles about Ethyl 2-hydrazinyl-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

oxalic acid diethyl ester (95-92-1) → ethyl 2-hydrazino-2-oxoacetate (35196-48-6)

Guidance literature:

With hydrazine hydrate; In ethanol; water; at -25 - 5 ℃; Solvent; Inert atmosphere;

Reference yield: 98.0%

ethyl 2-hydrazino-2-oxoacetate (35196-48-6) + 3,4-dimethoxy-benzaldehyde (120-14-9) → {N'-[1-(3,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-hydrazino}-oxo-acetic acid ethyl ester

Guidance literature:

In water; at 25 ℃; for 0.166667h; Green chemistry;

DOI:10.1016/j.tetlet.2018.04.047

Reference yield: 95.5%

ethyl 2-hydrazino-2-oxoacetate (35196-48-6) + 5-bromosalicyclaldehyde (1761-61-1) → C11H11BrN2O4

Guidance literature:

In water; at 25 ℃; for 2h; Green chemistry;

DOI:10.1016/j.tetlet.2018.04.047

upstream raw materials:

oxalic acid diethyl ester

Downstream raw materials:

oxalic acid ethyl ester-benzylidenehydrazide

ethyl ester of the p-methoxybenzylidenehydrazide of oxalic acid

oxalic acid monohydrazide

{N'-[1-(3-Bromo-phenyl)-meth-(E)-ylidene]-hydrazino}-oxo-acetic acid ethyl ester