(S)-2-((4-(TRIFLUOROMETHYL)PHENOXY)METHYL)OXIRANE

Base Information

• Chemical Name: (S)-2-((4-(TRIFLUOROMETHYL)PHENOXY)METHYL)OXIRANE
• CAS No.: 256372-58-4
• Molecular Formula: C10H9 F3 O2
• Molecular Weight: 218.175
• Mol file: 256372-58-4.mol

Synonyms:Oxirane,[[4-(trifluoromethyl)phenoxy]methyl]-, (2S)- (9CI);(S)-2-[[(4-Trifluoromethylphenyl)oxy]methyl]oxirane

Chemical Property of (S)-2-((4-(TRIFLUOROMETHYL)PHENOXY)METHYL)OXIRANE

Chemical Property:

• Boiling Point: 252.5±40.0 °C(Predicted)
• PSA: 21.76000
• Density: 1.304±0.06 g/cm3(Predicted)
• LogP: 2.48300

Purity/Quality:

97% ^*data from raw suppliers

(S)?-?4-?(Trifluoromethyl)?-?phenylGlycidylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)?-?4-?(Trifluoromethyl)?-?phenyl Glycidyl Ether is a glycidol derivative used in the preparation of organic compounds such as 2-?hydroxy-?3-?phenoxypropylpiperazine derivatives acting as T-type calcium channel blockers.

Technology Process of (S)-2-((4-(TRIFLUOROMETHYL)PHENOXY)METHYL)OXIRANE

There total 3 articles about (S)-2-((4-(TRIFLUOROMETHYL)PHENOXY)METHYL)OXIRANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-hydroxybenzotrifluoride (402-45-9) + (R)-oxiranemethanol (57044-25-4) → (S)-2-((4-(trifluoromethyl)phenoxy)methyl)oxirane (256372-58-4)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 48.38%

(S)-epichlorohydrin (67843-74-7,24969-06-0,13403-37-7) + 4-hydroxybenzotrifluoride (402-45-9) → (S)-2-((4-(trifluoromethyl)phenoxy)methyl)oxirane (256372-58-4)

Guidance literature:

4-hydroxybenzotrifluoride; With potassium carbonate; In butanone; at 20 ℃; for 0.166667h; Inert atmosphere; Schlenk technique;

(S)-epichlorohydrin; In butanone; at 90 ℃; for 15h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.bmcl.2012.12.072

Reference yield:

(S)-epichlorohydrin (67843-74-7,24969-06-0,13403-37-7) + 4-hydroxybenzotrifluoride (402-45-9) → (S)-2-((4-(trifluoromethyl)phenoxy)methyl)oxirane (256372-58-4) + C17H14F6O3

Guidance literature:

With caesium carbonate; In acetonitrile; Reflux;

DOI:10.1016/j.bmc.2009.04.005

upstream raw materials:

4-hydroxybenzotrifluoride

(R)-oxiranemethanol

(S)-epichlorohydrin

Downstream raw materials:

(R)-{4-[2-hydroxy-3-(4-trifluoromethyl-phenoxy)-propylsulfanyl]-2-methyl-phenoxy}-acetic acid ethyl ester

1-((R)-3-(4-(trifluoromethyl)phenoxy)-2-hydroxypropyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol

C₂₀H₂₂F₄N₂O₂

C₂₀H₂₂F₄N₂O₂

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