7,10-bis-O-(2,2,2,-trifluoroethoxycarbonyl)-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-10-deacetylbaccatin III

Base Information

Chemical Name:7,10-bis-O-(2,2,2,-trifluoroethoxycarbonyl)-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-10-deacetylbaccatin III
CAS No.:171251-33-5
Molecular Formula:C₄₇H₅₁Cl₆F₂NO₁₈
Molecular Weight:1168.63
Hs Code.:

Synonyms:7,10-bis-O-(2,2,2,-trifluoroethoxycarbonyl)-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-10-deacetylbaccatin III

Suppliers and Price of 7,10-bis-O-(2,2,2,-trifluoroethoxycarbonyl)-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-10-deacetylbaccatin III

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7,10-bis-O-(2,2,2,-trifluoroethoxycarbonyl)-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-10-deacetylbaccatin III

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7,10-bis-O-(2,2,2,-trifluoroethoxycarbonyl)-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-10-deacetylbaccatin III

There total 8 articles about 7,10-bis-O-(2,2,2,-trifluoroethoxycarbonyl)-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-10-deacetylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 95603-44-4
7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III

: 200501-25-3
(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionic acid

: 171251-33-5
7,10-bis-O-(2,2,2,-trifluoroethoxycarbonyl)-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-10-deacetylbaccatin III

Guidance literature:: With dmap; diphenylcyclopropenone; In toluene; at 80 ℃; for 60h;
DOI:10.1248/cpb.45.1793

Reference yield:

: 98-01-1
furfural

: 171251-33-5
7,10-bis-O-(2,2,2,-trifluoroethoxycarbonyl)-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-10-deacetylbaccatin III

Guidance literature:: Multi-step reaction with 9 steps

1: 100 percent / Na₂SO₄ / benzene / 0.5 h / Ambient temperature

2: zinc / tetrahydrofuran / 0.5 h / Heating

4: 1M aq. NaOH / tetrahydrofuran / 1 h

5: thionyl chloride / 15 h / 80 °C

6: CAN / H₂O; acetonitrile / 0.5 h / Ambient temperature

7: tetrahydrofuran / 18 h / 60 °C

8: 78 percent / LiOH / ethanol; H₂O / 0.5 h / Ambient temperature

9: 86 percent / DPC, 4-(dimethylamino)pyridine / toluene / 60 h / 80 °C

With dmap; lithium hydroxide; sodium hydroxide; thionyl chloride; ammonium cerium(IV) nitrate; sodium sulfate; diphenylcyclopropenone; zinc; In tetrahydrofuran; ethanol; water; toluene; acetonitrile; benzene;
DOI:10.1248/cpb.45.1793

Reference yield:

: 1749-14-0,100239-11-0
N-furfurylidene-p-anisidine

: 171251-33-5
7,10-bis-O-(2,2,2,-trifluoroethoxycarbonyl)-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-10-deacetylbaccatin III

Guidance literature:: Multi-step reaction with 8 steps

1: zinc / tetrahydrofuran / 0.5 h / Heating

3: 1M aq. NaOH / tetrahydrofuran / 1 h

4: thionyl chloride / 15 h / 80 °C

5: CAN / H₂O; acetonitrile / 0.5 h / Ambient temperature

6: tetrahydrofuran / 18 h / 60 °C

7: 78 percent / LiOH / ethanol; H₂O / 0.5 h / Ambient temperature

8: 86 percent / DPC, 4-(dimethylamino)pyridine / toluene / 60 h / 80 °C

With dmap; lithium hydroxide; sodium hydroxide; thionyl chloride; ammonium cerium(IV) nitrate; diphenylcyclopropenone; zinc; In tetrahydrofuran; ethanol; water; toluene; acetonitrile;
DOI:10.1248/cpb.45.1793