4-{(1R)-1-fluoro-1-methyl-2-[(methylsulfonyl)amino]-2-oxoethyl}phenyl trifluoromethanesulfonate

Base Information

Chemical Name:4-{(1R)-1-fluoro-1-methyl-2-[(methylsulfonyl)amino]-2-oxoethyl}phenyl trifluoromethanesulfonate
CAS No.:1034809-33-0
Molecular Formula:C₁₁H₁₁F₄NO₆S₂
Molecular Weight:393.337
Hs Code.:

Synonyms:4-{(1R)-1-fluoro-1-methyl-2-[(methylsulfonyl)amino]-2-oxoethyl}phenyl trifluoromethanesulfonate

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Chemical Property of 4-{(1R)-1-fluoro-1-methyl-2-[(methylsulfonyl)amino]-2-oxoethyl}phenyl trifluoromethanesulfonate

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Technology Process of 4-{(1R)-1-fluoro-1-methyl-2-[(methylsulfonyl)amino]-2-oxoethyl}phenyl trifluoromethanesulfonate

There total 7 articles about 4-{(1R)-1-fluoro-1-methyl-2-[(methylsulfonyl)amino]-2-oxoethyl}phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3144-09-0
methanesulfonamide

: 1034809-06-7
(2R)-2-fluoro-2-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)propanoic acid

: 1034809-33-0
4-{(1R)-1-fluoro-1-methyl-2-[(methylsulfonyl)amino]-2-oxoethyl}phenyl trifluoromethanesulfonate

Guidance literature:: (2R)-2-fluoro-2-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)propanoic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; for 1h;

methanesulfonamide; With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1034809-42-1
4-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)phenyl trifluoromethanesulfonate

: 1034809-33-0
4-{(1R)-1-fluoro-1-methyl-2-[(methylsulfonyl)amino]-2-oxoethyl}phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 1.5 h / -78 °C

1.2: 20 °C

2.1: ammonia / methanol / 20 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / -60 - 20 °C

4.1: hydrogenchloride; water / 1,4-dioxane / 48 h / Heating / reflux

5.1: cinchonidine / isopropyl alcohol / Heating / reflux; Resolution of racemate

6.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h

6.2: 20 °C

With hydrogenchloride; diethylamino-sulfur trifluoride; ammonia; water; cinchonidine; 1,1'-carbonyldiimidazole; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; isopropyl alcohol;

Reference yield:

: 1034809-02-3
(R,S)-2-[4-(trifluoromethanesulfonyloxy)phenyl]-2-fluoro-propanoic acid

: 1034809-33-0
4-{(1R)-1-fluoro-1-methyl-2-[(methylsulfonyl)amino]-2-oxoethyl}phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: cinchonidine / isopropyl alcohol / Heating / reflux; Resolution of racemate

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h

2.2: 20 °C

With cinchonidine; 1,1'-carbonyldiimidazole; In dichloromethane; isopropyl alcohol;