methyl O-[(4-fluorophenyl)carbamoyl]-N-formyl-N-(4'-methylbiphenyl-4-yl)homoserinate

Base Information

Chemical Name:methyl O-[(4-fluorophenyl)carbamoyl]-N-formyl-N-(4'-methylbiphenyl-4-yl)homoserinate
CAS No.:1369963-03-0
Molecular Formula:C₂₆H₂₅FN₂O₅
Molecular Weight:464.493
Hs Code.:

Synonyms:methyl O-[(4-fluorophenyl)carbamoyl]-N-formyl-N-(4'-methylbiphenyl-4-yl)homoserinate

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Chemical Property of methyl O-[(4-fluorophenyl)carbamoyl]-N-formyl-N-(4'-methylbiphenyl-4-yl)homoserinate

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Technology Process of methyl O-[(4-fluorophenyl)carbamoyl]-N-formyl-N-(4'-methylbiphenyl-4-yl)homoserinate

There total 7 articles about methyl O-[(4-fluorophenyl)carbamoyl]-N-formyl-N-(4'-methylbiphenyl-4-yl)homoserinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369963-01-8
methyl N-formyl-N-(4'-methylbiphenyl-4-yl)homoserinate

: 1195-45-5
para-fluorophenyl isocyanate

: 1369963-03-0
methyl O-[(4-fluorophenyl)carbamoyl]-N-formyl-N-(4'-methylbiphenyl-4-yl)homoserinate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 1369963-03-0
methyl O-[(4-fluorophenyl)carbamoyl]-N-formyl-N-(4'-methylbiphenyl-4-yl)homoserinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 h / 20 °C

3.1: 3 h / 100 - 110 °C

4.1: toluene / 9 h / Reflux

5.1: sodium hydroxide; water / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 20 °C

6.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With water; hydrogen; potassium carbonate; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 586-78-7
para-nitrophenyl bromide

: 1369963-03-0
methyl O-[(4-fluorophenyl)carbamoyl]-N-formyl-N-(4'-methylbiphenyl-4-yl)homoserinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 h / 20 °C

3.1: 3 h / 100 - 110 °C

4.1: toluene / 9 h / Reflux

5.1: sodium hydroxide; water / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 20 °C

6.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With water; hydrogen; potassium carbonate; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;