(RS)-methyl α-(methoxymethyl)-3,5-bis(trifluoromethyl)benzeneacetate

Base Information

• Chemical Name: (RS)-methyl α-(methoxymethyl)-3,5-bis(trifluoromethyl)benzeneacetate
• CAS No.: 374794-66-8
• Molecular Formula: C₁₃H₁₂F₆O₃
• Molecular Weight: 330.227
• Mol file: 374794-66-8.mol

Synonyms:(RS)-methyl α-(methoxymethyl)-3,5-bis(trifluoromethyl)benzeneacetate

Chemical Property of (RS)-methyl α-(methoxymethyl)-3,5-bis(trifluoromethyl)benzeneacetate

Chemical Property:

Purity/Quality:

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Technology Process of (RS)-methyl α-(methoxymethyl)-3,5-bis(trifluoromethyl)benzeneacetate

There total 1 articles about (RS)-methyl α-(methoxymethyl)-3,5-bis(trifluoromethyl)benzeneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(RS)-methyl α-(hydroxymethyl)-3,5-bis(trifluoromethyl)benzeneacetate (374794-37-3) + diazomethyl-trimethyl-silane (18107-18-1) → (RS)-methyl α-(methoxymethyl)-3,5-bis(trifluoromethyl)benzeneacetate (374794-66-8)

Guidance literature:

With fluoroboric acid; In dichloromethane; water; at 20 ℃; for 1.5h;

Reference yield: 16.0%

(RS)-methyl α-(methoxymethyl)-3,5-bis(trifluoromethyl)benzeneacetate (374794-66-8) → (RS)-α-(methoxymethyl)-3,5-bis(trifluoroethyl)benzeneacetic acid (374794-67-9)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 20h;

upstream raw materials:

(RS)-methyl α-(hydroxymethyl)-3,5-bis(trifluoromethyl)benzeneacetate

diazomethyl-trimethyl-silane

Downstream raw materials:

(RS)-α-(methoxymethyl)-3,5-bis(trifluoroethyl)benzeneacetic acid