2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-oxo-2-(3,5-dichloro-phenyl)acetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

Base Information

Chemical Name:2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-oxo-2-(3,5-dichloro-phenyl)acetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid
CAS No.:1445604-03-4
Molecular Formula:C₃₃H₃₃Cl₂NO₉
Molecular Weight:658.532
Hs Code.:

Synonyms:2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-oxo-2-(3,5-dichloro-phenyl)acetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

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Chemical Property of 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-oxo-2-(3,5-dichloro-phenyl)acetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

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Technology Process of 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-oxo-2-(3,5-dichloro-phenyl)acetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

There total 4 articles about 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-oxo-2-(3,5-dichloro-phenyl)acetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1445604-12-5
C₃₇H₄₁Cl₂NO₉

: 1445604-03-4
2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-oxo-2-(3,5-dichloro-phenyl)acetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;

Reference yield:

: 3105-95-1,83680-83-5
pipecolinic acid

: 1445604-03-4
2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-oxo-2-(3,5-dichloro-phenyl)acetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / 1,4-dioxane / 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

3: 4-methylpiperidin / dichloromethane / 4 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

With 4-methylpiperidin; dmap; potassium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;

Reference yield:

: 101555-63-9,105751-19-7,86069-86-5
(S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid

: 1445604-03-4
2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-oxo-2-(3,5-dichloro-phenyl)acetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

2: 4-methylpiperidin / dichloromethane / 4 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

With 4-methylpiperidin; dmap; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;