(E)-(R)-4-{(2R,3R,4R,5S)-3,4-Dihydroxy-5-[2-(1-phenyl-1H-tetrazole-5-sulfonyl)-ethyl]-tetrahydro-pyran-2-yl}-3-methyl-4-triisopropylsilanyloxy-but-2-enoic acid ethyl ester

Base Information

Chemical Name:(E)-(R)-4-{(2R,3R,4R,5S)-3,4-Dihydroxy-5-[2-(1-phenyl-1H-tetrazole-5-sulfonyl)-ethyl]-tetrahydro-pyran-2-yl}-3-methyl-4-triisopropylsilanyloxy-but-2-enoic acid ethyl ester
CAS No.:848188-03-4
Molecular Formula:C₃₀H₄₈N₄O₈SSi
Molecular Weight:652.885
Hs Code.:

(E)-(R)-4-{(2R,3R,4R,5S)-3,4-Dihydroxy-5-[2-(1-phenyl-1H-tetrazole-5-sulfonyl)-ethyl]-tetrahydro-pyran-2-yl}-3-methyl-4-triisopropylsilanyloxy-but-2-enoic acid ethyl ester

Synonyms:(E)-(R)-4-{(2R,3R,4R,5S)-3,4-Dihydroxy-5-[2-(1-phenyl-1H-tetrazole-5-sulfonyl)-ethyl]-tetrahydro-pyran-2-yl}-3-methyl-4-triisopropylsilanyloxy-but-2-enoic acid ethyl ester

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Chemical Property of (E)-(R)-4-{(2R,3R,4R,5S)-3,4-Dihydroxy-5-[2-(1-phenyl-1H-tetrazole-5-sulfonyl)-ethyl]-tetrahydro-pyran-2-yl}-3-methyl-4-triisopropylsilanyloxy-but-2-enoic acid ethyl ester

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Technology Process of (E)-(R)-4-{(2R,3R,4R,5S)-3,4-Dihydroxy-5-[2-(1-phenyl-1H-tetrazole-5-sulfonyl)-ethyl]-tetrahydro-pyran-2-yl}-3-methyl-4-triisopropylsilanyloxy-but-2-enoic acid ethyl ester

There total 9 articles about (E)-(R)-4-{(2R,3R,4R,5S)-3,4-Dihydroxy-5-[2-(1-phenyl-1H-tetrazole-5-sulfonyl)-ethyl]-tetrahydro-pyran-2-yl}-3-methyl-4-triisopropylsilanyloxy-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 848187-92-8
(E)-(R)-3-Methyl-4-{(2R,5R)-5-[2-(1-phenyl-1H-tetrazole-5-sulfonyl)-ethyl]-5,6-dihydro-2H-pyran-2-yl}-4-triisopropylsilanyloxy-but-2-enoic acid ethyl ester

: 848188-03-4
(E)-(R)-4-{(2R,3R,4R,5S)-3,4-Dihydroxy-5-[2-(1-phenyl-1H-tetrazole-5-sulfonyl)-ethyl]-tetrahydro-pyran-2-yl}-3-methyl-4-triisopropylsilanyloxy-but-2-enoic acid ethyl ester

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; tert-butyl alcohol; at 20 ℃;
DOI:10.1021/ja042827p

Reference yield:

: 62054-49-3
ethyl (E)-3-formyl-2-butenoate

: 848188-03-4
(E)-(R)-4-{(2R,3R,4R,5S)-3,4-Dihydroxy-5-[2-(1-phenyl-1H-tetrazole-5-sulfonyl)-ethyl]-tetrahydro-pyran-2-yl}-3-methyl-4-triisopropylsilanyloxy-but-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 76 percent / 48 h / 110 °C

2.1: 93 percent / 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

3.1: OsO₄; potassium ferricyanide; (DHDQ)2PHAL / K₂CO₃; methanesulfonamide / 2-methyl-propan-2-ol; H₂O / 2 h / 0 °C

3.2: NaIO₄ / tetrahydrofuran; H₂O / 1 h / 20 °C

4.1: 8.98 g / NaBH₄ / ethanol / 0.5 h

5.1: 85 percent / TiCl₄; Et₃SiH / CH₂Cl₂ / 2.5 h / -50 °C

6.1: PPh₃; DIAD / tetrahydrofuran / 4 h / 20 °C

7.1: 7.65 g / aq. H₂O₂; ammonium molybdate tetrahydrate / ethanol / 20 °C

8.1: 87 percent / OsO₄; N-methylmorpholine N-oxide monohydrate / acetone; H₂O; 2-methyl-propan-2-ol / 20 °C

With 2,6-dimethylpyridine; triethylsilane; sodium tetrahydroborate; osmium(VIII) oxide; ammonium molybdate(VI) tetrahydrate; di-isopropyl azodicarboxylate; dihydrogen peroxide; titanium tetrachloride; 4-methylmorpholine N-oxide; 1,4-bis(9-O-dihydroquinidine)phthalazine; triphenylphosphine; potassium hexacyanoferrate(III); methanesulfonamide; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1021/ja042827p

Reference yield:

: (2S,3R,4R)-2-Ethoxy-3-(3-methyl-but-2-enyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-2H-pyran

: 848188-03-4
(E)-(R)-4-{(2R,3R,4R,5S)-3,4-Dihydroxy-5-[2-(1-phenyl-1H-tetrazole-5-sulfonyl)-ethyl]-tetrahydro-pyran-2-yl}-3-methyl-4-triisopropylsilanyloxy-but-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 76 percent / 48 h / 110 °C

2.1: 93 percent / 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

3.1: OsO₄; potassium ferricyanide; (DHDQ)2PHAL / K₂CO₃; methanesulfonamide / 2-methyl-propan-2-ol; H₂O / 2 h / 0 °C

3.2: NaIO₄ / tetrahydrofuran; H₂O / 1 h / 20 °C

4.1: 8.98 g / NaBH₄ / ethanol / 0.5 h

5.1: 85 percent / TiCl₄; Et₃SiH / CH₂Cl₂ / 2.5 h / -50 °C

6.1: PPh₃; DIAD / tetrahydrofuran / 4 h / 20 °C

7.1: 7.65 g / aq. H₂O₂; ammonium molybdate tetrahydrate / ethanol / 20 °C

8.1: 87 percent / OsO₄; N-methylmorpholine N-oxide monohydrate / acetone; H₂O; 2-methyl-propan-2-ol / 20 °C

With 2,6-dimethylpyridine; triethylsilane; sodium tetrahydroborate; osmium(VIII) oxide; ammonium molybdate(VI) tetrahydrate; di-isopropyl azodicarboxylate; dihydrogen peroxide; titanium tetrachloride; 4-methylmorpholine N-oxide; 1,4-bis(9-O-dihydroquinidine)phthalazine; triphenylphosphine; potassium hexacyanoferrate(III); methanesulfonamide; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1021/ja042827p