ethyl 6-(((S)-3-((((S)-2-amino-3-methylbutanoyl)oxy)methyl)morpholino)methyl)-4-(2-bromo-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Base Information

Chemical Name:ethyl 6-(((S)-3-((((S)-2-amino-3-methylbutanoyl)oxy)methyl)morpholino)methyl)-4-(2-bromo-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
CAS No.:1571213-28-9
Molecular Formula:C₂₇H₃₃BrFN₅O₅S
Molecular Weight:638.558
Hs Code.:

ethyl 6-(((S)-3-((((S)-2-amino-3-methylbutanoyl)oxy)methyl)morpholino)methyl)-4-(2-bromo-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Synonyms:ethyl 6-(((S)-3-((((S)-2-amino-3-methylbutanoyl)oxy)methyl)morpholino)methyl)-4-(2-bromo-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

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Chemical Property of ethyl 6-(((S)-3-((((S)-2-amino-3-methylbutanoyl)oxy)methyl)morpholino)methyl)-4-(2-bromo-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

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Technology Process of ethyl 6-(((S)-3-((((S)-2-amino-3-methylbutanoyl)oxy)methyl)morpholino)methyl)-4-(2-bromo-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

There total 5 articles about ethyl 6-(((S)-3-((((S)-2-amino-3-methylbutanoyl)oxy)methyl)morpholino)methyl)-4-(2-bromo-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: C₃₂H₄₁BrFN₅O₇S

: 1571213-28-9
ethyl 6-(((S)-3-((((S)-2-amino-3-methylbutanoyl)oxy)methyl)morpholino)methyl)-4-(2-bromo-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 25 ℃; for 12h;

Reference yield: 54.0%

: 13734-41-3
t-Boc-L-valine

: ethyl 4-(2-bromo-4-fluorophenyl)-6-(((S)-3-(hydroxycarbamoyl)morpholino)methyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

: 1571213-28-9
ethyl 6-(((S)-3-((((S)-2-amino-3-methylbutanoyl)oxy)methyl)morpholino)methyl)-4-(2-bromo-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Guidance literature:: t-Boc-L-valine; ethyl 4-(2-bromo-4-fluorophenyl)-6-(((S)-3-(hydroxycarbamoyl)morpholino)methyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 12.25h;

With hydrogenchloride; In dichloromethane; ethyl acetate; at 25 ℃; for 12h;

Reference yield:

: 1092953-04-2
ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(thiazol-2-yl)-1,4-dihydro-pyrimidine-5-carboxylate

: 1571213-28-9
ethyl 6-(((S)-3-((((S)-2-amino-3-methylbutanoyl)oxy)methyl)morpholino)methyl)-4-(2-bromo-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / ethanol / 16 h / 25 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / -10 °C

2.2: 12 h / -10 - 25 °C

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12.25 h / 20 °C

3.2: 12 h / 25 °C

With dmap; 1-hydroxy-7-aza-benzotriazole; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;