(R)-tert-Butyl₂-((tert-butoxycarbonyl)amino)-3-(((2S,3R)-6,6,6-trifluoro-3-(((S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanamido)thio)propanoate

Base Information

• Chemical Name: (R)-tert-Butyl₂-((tert-butoxycarbonyl)amino)-3-(((2S,3R)-6,6,6-trifluoro-3-(((S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanamido)thio)propanoate
• CAS No.: 1581704-64-4
• Molecular Formula: C₃₇H₄₅F₆N₅O₇S
• Molecular Weight: 817.85

Synonyms:(R)-tert-Butyl₂-((tert-butoxycarbonyl)amino)-3-(((2S,3R)-6,6,6-trifluoro-3-(((S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanamido)thio)propanoate

Chemical Property of (R)-tert-Butyl₂-((tert-butoxycarbonyl)amino)-3-(((2S,3R)-6,6,6-trifluoro-3-(((S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanamido)thio)propanoate

Chemical Property:

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Technology Process of (R)-tert-Butyl₂-((tert-butoxycarbonyl)amino)-3-(((2S,3R)-6,6,6-trifluoro-3-(((S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanamido)thio)propanoate

There total 3 articles about (R)-tert-Butyl₂-((tert-butoxycarbonyl)amino)-3-(((2S,3R)-6,6,6-trifluoro-3-(((S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanamido)thio)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.4%

(2R,3S)-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide (1401066-80-5) + tert-butyl (2R)-3-{[(2R)-3-(tert-butoxy)-2-{[(tert-butoxy)carbonyl]amino}-3-oxopropyl]disulfanyl}-2-{[(tert-butoxy)carbonyl]amino}propanoate (98303-76-5) → (R)-tert-Butyl2-((tert-butoxycarbonyl)amino)-3-(((2S,3R)-6,6,6-trifluoro-3-(((S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanamido)thio)propanoate (1581704-64-4)

Guidance literature:

tert-butyl (2R)-3-{[(2R)-3-(tert-butoxy)-2-{[(tert-butoxy)carbonyl]amino}-3-oxopropyl]disulfanyl}-2-{[(tert-butoxy)carbonyl]amino}propanoate; With silver nitrate; In methanol; for 0.5h;

(2R,3S)-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide; With triethylamine; at 20 ℃;

Reference yield:

L-cystine tert-butyl ester (62574-13-4) → (R)-tert-Butyl2-((tert-butoxycarbonyl)amino)-3-(((2S,3R)-6,6,6-trifluoro-3-(((S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanamido)thio)propanoate (1581704-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.17 h / 20 °C

1.2: 12 h / 20 °C

2.1: silver nitrate / methanol / 0.5 h

2.2: 20 °C

With silver nitrate; triethylamine; In tetrahydrofuran; methanol;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (R)-tert-Butyl2-((tert-butoxycarbonyl)amino)-3-(((2S,3R)-6,6,6-trifluoro-3-(((S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanamido)thio)propanoate (1581704-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.17 h / 20 °C

1.2: 12 h / 20 °C

2.1: silver nitrate / methanol / 0.5 h

2.2: 20 °C

With silver nitrate; triethylamine; In tetrahydrofuran; methanol;

upstream raw materials:

(2R,3S)-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

tert-butyl (2R)-3-{[(2R)-3-(tert-butoxy)-2-{[(tert-butoxy)carbonyl]amino}-3-oxopropyl]disulfanyl}-2-{[(tert-butoxy)carbonyl]amino}propanoate

L-cystine tert-butyl ester

di-tert-butyl dicarbonate

Downstream raw materials:

S-(((2S,3R)-6,6,6-trifluoro-3-(((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanoyl)amino)-L-cysteine

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