ethyl-1-(6-chloro-3,4-methylenedioxybenzyl)-5-(benzyloxy)indolecarboxylate

Base Information

• Chemical Name: ethyl-1-(6-chloro-3,4-methylenedioxybenzyl)-5-(benzyloxy)indolecarboxylate
• CAS No.: 197841-22-8
• Molecular Formula: C₂₄H₁₈ClNO₅
• Molecular Weight: 435.864
• Mol file: 197841-22-8.mol

Synonyms:ethyl-1-(6-chloro-3,4-methylenedioxybenzyl)-5-(benzyloxy)indolecarboxylate

Chemical Property of ethyl-1-(6-chloro-3,4-methylenedioxybenzyl)-5-(benzyloxy)indolecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl-1-(6-chloro-3,4-methylenedioxybenzyl)-5-(benzyloxy)indolecarboxylate

There total 2 articles about ethyl-1-(6-chloro-3,4-methylenedioxybenzyl)-5-(benzyloxy)indolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

→ ethyl-1-(6-chloro-3,4-methylenedioxybenzyl)-5-(benzyloxy)indolecarboxylate (197841-22-8)

Guidance literature:

Reference yield: 66.0%

1-dichloromethyl-3,4-methylenedioxybenzene (10584-67-5) + 5-benzyloxy-1H-indole-2-carboxylic acid ethyl ester (37033-95-7) → ethyl-1-(6-chloro-3,4-methylenedioxybenzyl)-5-(benzyloxy)indolecarboxylate (197841-22-8)

Guidance literature:

5-benzyloxy-1H-indole-2-carboxylic acid ethyl ester; With sodium hydride; In hexane; N,N-dimethyl-formamide; at 20 ℃; for 1h;

1-dichloromethyl-3,4-methylenedioxybenzene; In hexane; N,N-dimethyl-formamide; at 20 ℃; for 24h; Further stages.;

DOI:10.1021/jm025571b

Reference yield:

ethyl-1-(6-chloro-3,4-methylenedioxybenzyl)-5-(benzyloxy)indolecarboxylate (197841-22-8) → 2-carboxy-1-(6-chloropiperonyl)-5-(2,6-dichlorobenzyloxy)indole

Guidance literature:

Multi-step reaction with 2 steps

1.1: 80 percent / Pd/C / ethyl acetate / 18 h / 3102.97 Torr

2.1: NaH / hexane; dimethylformamide / 1 h / 20 °C

2.2: 82 percent / hexane; dimethylformamide / 1 h / 20 °C

With sodium hydride; palladium on activated charcoal; In hexane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm025571b

upstream raw materials:

1-dichloromethyl-3,4-methylenedioxybenzene

5-benzyloxy-1H-indole-2-carboxylic acid ethyl ester